Results 181 to 190 of about 4,713,645 (328)

Semiparametric profile likelihood estimation for continuous outcomes with excess zeros in a random-threshold damage-resistance model. [PDF]

Stat Med, 2017
Rice JD, Tsodikov A.
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Profile-likelihood Bayesian model averaging for two-sample summary data Mendelian randomization in the presence of horizontal pleiotropy [PDF]

, 2020
Chin Yang Shapland, Qingyuan Zhao, Jack Bowden   +2 more
openalex   +1 more source

Evaluating Testing, Profile Likelihood Confidence Interval Estimation, and Model Comparisons for Item Covariate Effects in Linear Logistic Test Models. [PDF]

Appl Psychol Meas, 2017
Cho SJ, De Boeck P, Lee WY.
europepmc   +1 more source

Supplement 2. R code for constructing profile likelihood confidence intervals and evaluating fit of the stochastic linear immigration–death model fit to example sage-grouse fence collision data.

, 2016
Bryan S. Stevens, Brian Dennis
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evolving Improved Sampling Protocols for Dose-Response Modelling Using Genetic Algorithms with a Profile-Likelihood Metric. [PDF]

Bull Math Biol
Lam NN, Murray R, Docherty PD.
europepmc   +1 more source

Appendix A. Further discussion on the theta-Ricker and generalized Beverton-Holt density-dependent models, a complete description of likelihood equations and methods of parameter estimation, elaboration on the simulation experiment, additional analyses of the Accipiter nisus data set, TRPN best-fit and ALT models for 25 additional time series from the GPDD, and a presentation of the joint profile likelihood surface of a Columba oenas data set for comparison with Bayesian posterior densities.

, 2016
Leo Polansky, Perry de Valpine, James O. Lloyd‐Smith, Wayne M. Getz   +3 more
openalex   +1 more source

Quantification of oxygen metabolic rates in Human brain with dynamic 17O MRI: Profile likelihood analysis

Magnetic Resonance in Medicine, 2017
Dmitry Kurzhunov, R. Borowiak, Helge Hass, Philipp Wagner, A. Krafft, J. Timmer, M. Bock   +6 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source