Results 81 to 90 of about 4,713,645 (328)

The impact of priors and observables on parameter inferences in the Constrained MSSM [PDF]

, 2008
We use a newly released version of the SuperBayeS code to analyze the impact of the choice of priors and the influence of various constraints on the statistical conclusions for the preferred values of the parameters of the Constrained MSSM. We assess the
de Austri, R. Ruiz, Feroz, F., Hobson, M. P., Roszkowski, L., Trotta, R.   +4 more
core   +2 more sources

Profile likelihood maps of a 15-dimensional MSSM [PDF]

Journal of High Energy Physics, 2014
We present statistically convergent profile likelihood maps obtained via global fits of a phenomenological Minimal Supersymmetric Standard Model with 15 free parameters (the MSSM-15), based on over 250M points.
C. Strege, G. Bertone, G. Besjes, S. Caron, R. R. Austri, A. Strubig, R. Trotta   +6 more
semanticscholar   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Identifiability investigation of within-host models of acute virus infection

Mathematical Biosciences and Engineering
Uncertainty in parameter estimates from fitting within-host models to empirical data limits the model's ability to uncover mechanisms of infection, disease progression, and to guide pharmaceutical interventions.
Yuganthi R. Liyanage, Nora Heitzman-Breen, Necibe Tuncer, Stanca M. Ciupe   +3 more
doaj   +1 more source

Improving soil moisture profile reconstruction from ground-penetrating radar data: a maximum likelihood ensemble filter approach [PDF]

Hydrology and Earth System Sciences, 2013
The vertical profile of shallow unsaturated zone soil moisture plays a key role in many hydro-meteorological and agricultural applications. We propose a closed-loop data assimilation procedure based on the maximum likelihood ensemble filter algorithm to ...
A. P. Tran, M. Vanclooster, S. Lambot
doaj   +1 more source

Improving likelihood-based inference in control rate regression [PDF]

, 2017
Control rate regression is a diffuse approach to account for heterogeneity among studies in meta-analysis by including information about the outcome risk of patients in the control condition.
Guolo, Annamaria
core   +2 more sources

Adjusted Versions of Profile Likelihood and Directed Likelihood, and Extended Likelihood

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1994
SUMMARY Several adjusted and invariant versions of profile likelihood and of directed likelihood (short for signed log-likelihood ratio) are discussed. These adjusted versions, which fall into two groups, are closely related to modified profile likelihood and modified directed likelihood.
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source