Results 81 to 90 of about 333,801 (297)
Censored median regression and profile empirical likelihood
, 2007 We implement profile empirical likelihood-based inference for censored median regression models. Inference for any specified subvector is carried out by profiling out the nuisance parameters from the plug-in empirical likelihood ratio function proposed
Subramanian, Sundarraman
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A Nonparametric Bayesian Approach to the Rare Type Match Problem
Entropy, 2020 The “rare type match problem” is the situation in which, in a criminal case, the suspect’s DNA profile, matching the DNA profile of the crime stain, is not in the database of reference.
Giulia Cereda, Richard D. Gill
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Reduce computation in profile empirical likelihood method [PDF]
, 2011 Since its introduction by Owen in [29, 30], the empirical likelihood method has been extensively investigated and widely used to construct confidence regions and to test hypotheses in the literature.
Peng, Liang +5 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Adjustements of the profile likelihood from a new perspective. [PDF]
, 2003 Various modifications of the profile likelihood have been proposed over the past twenty years. Their main theoretical basis is higher-order approximation of some target likelihood, defined by a suitable model reduction via conditioning or marginalisation,
Salvan , Alessandra +2 more
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Estimated parameters versus the profile likelihood function for Japan.
, 2022 (a), (b), and (c) show the graphs of estimated parameters versus the profile likelihood function for the first, second, and third waves, respectively.
Masud M. A. (13570175) +4 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Likelihood inference for small variance components
, 2000 In this paper, we develop likelihood-based methods for making inferences about the components of variance in a general normal mixed linear model. In particular, we use local asymptotic approximations to construct confidence intervals for the components ...
Stern, S.E., Welsh, A.H.
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