Results 81 to 90 of about 2,698,368 (301)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Challenges of profile likelihood evaluation in multi-dimensional SUSY scans [PDF]

, 2011
Statistical inference of the fundamental parameters of supersymmetric theories is a challenging and active endeavor. Several sophisticated algorithms have been employed to this end. While Markov-Chain Monte Carlo (MCMC) and nested sampling techniques are
Trotta, R, Roberto Ruiz de Austri, Trotta R., Mike Hobson, Roberto Trotta, Cranmer, K, Ruiz de Austri, R, Feroz F., Feroz, F, Cranmer K., Hobson, M, De Austri R. R., Hobson M., Kyle Cranmer, Farhan Feroz   +14 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A SAS Package for Logistic Two-Phase Studies

Journal of Statistical Software, 2014
Two-phase designs, in which for a large study a dichotomous outcome and partial or proxy information on risk factors is available, whereas precise or complete measurements on covariates have been obtained only in a stratified sub-sample, extend the ...
Walter Schill, Dirk Enders, Karsten Drescher   +2 more
doaj   +1 more source

Likelihood-based Imprecise Regression [PDF]

, 2011
We introduce a new approach to regression with imprecisely observed data, combining likelihood inference with ideas from imprecise probability theory, and thereby taking different kinds of uncertainty into account.
Marco E. G. V. Cattaneo, Wiencierz, Andrea, Cattaneo, Marco E. G. V., Andrea Wiencierz   +3 more
core   +1 more source

A Note on the Calculation of Adjusted Profile Likelihood

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1993
SUMMARY An adjustment to the profile likelihood examined by Cox and Reid required orthogonalization of the nuisance parameters with respect to the parameter of interest. An approximation to the adjusted profile likelihood not requiring explicit orthogonalization is derived and exemplified.
Cox, D. R., Reid, N.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Measuring Risk Likelihood in Cybersecurity

Applied Sciences
Cybersecurity risk is commonly expressed through impact and likelihood, yet likelihood remains difficult to estimate because cyber incidents are underreported, heterogeneous datasets are weakly comparable, and attacker behavior changes faster than ...
Pablo Corona-Fraga, Vanessa Díaz-Rodriguez, Jesús Manuel Niebla-Zatarain, Gabriel Sánchez-Pérez   +3 more
doaj   +1 more source

Reduce computation in profile empirical likelihood method [PDF]

Since its introduction by Owen in [29, 30], the empirical likelihood method has been extensively investigated and widely used to construct confidence regions and to test hypotheses in the literature.
Peng, Liang, Li, Minqiang, Qi, Yongcheng
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source