Results 111 to 120 of about 5,008,337 (326)

CoFeD: A visualisation framework for comparative quality evaluation [PDF]

open access: yes, 2017
Evaluation for the purpose of selection can be a challenging task particularly when there is a plethora of choices available. Short-listing, comparisons and eventual choice(s) can be aided by visualisation techniques.
Comley , Richard   +2 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

The effect of profiling report on antibiotic prescription for upper respiratory tract infection [PDF]

open access: yesMalaysian Family Physician, 2013
Introduction: Upper respiratory tract infection (URTI) is a common encounter in primary care and mostly viral in origin. Despite frequent reminders to primary care providers on judicious use of antibiotics for URTI, the practice is still rampant. Methods:
Mohd Fozi K, Kamaliah MN
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

OSL Characterisation of Two Fluvial Sequences of the River Usmacinta in its Middle Catchment (SE Mexico) [PDF]

open access: yes, 2014
The report summarizes luminescence profiling, initially using a SUERC PPSL system in Mexico, and laboratory analysis at SUERC, used to characterise the stratigraphy and interpret sedimentary processes in terrace deposits of the Usumacinta River, SE ...
Castillo Rodriguez, Miguel   +4 more
core  

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

open access: yesbioRxiv, 2017
A cytometric imaging approach, called CO-Detection by indEXing (CODEX), that enables high parameter multiplexing of antibody-tagged target epitopes is used here to create high parameter imaging datasets of normal mouse and lupus (MRL/lpr) spleens.
Y. Goltsev   +7 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Smart Device Profiling for Smart SCADA [PDF]

open access: yes, 2011
SCADA (Supervisory Control and Data Acquisition) systems are computer systems used for monitoring and controlling industrial processes such as power plants and power grid systems, water, gas and oil distribution systems, production systems for food, cars
Bolzoni, Damiano   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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