Results 181 to 190 of about 704,038 (263)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Molecular profiling and personalized medicine within EURACAN in the SPECTA Arcagen study in comparison to the France Genomic Medicine 2025 Plan in the AURAGEN platform in peritoneal mesotheliomas. [PDF]

Transl Oncol
Momenkhan S, Morfouace M, Kepenekian V, Glehen O, Villeneuve L, Oliveira J, Tejpar S, Isaac S, Fontaine J, Blay JY, Péron J, Benzerdjeb N.   +11 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Correction to "Integrating multimodal management and molecular profiling in a patient with BRAF V600E-positive melanoma and brain metastases". [PDF]

CA Cancer J Clin
europepmc   +1 more source

Progress and new challenges in image-based profiling. [PDF]

Mol Syst Biol
Serrano E, Peters J, Wagner J, Graham RE, Chen Z, Feng BY, Miranda G, Kalinin AA, Vulliard L, Tomkinson J, Mattson C, Lippincott MJ, Kang Z, Sitani D, Bunten D, Seal S, Carragher NO, Carpenter AE, Singh S, Marin Zapata PA, Caicedo JC, Way GP.   +21 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Compositional profiling for biodegradable medical devices: a framework for degradation-informed exposure and risk assessment. [PDF]

Front Toxicol
Wilsey J, Potapova I, Wu S, Weng MW, Lewis M, Wang H, Rufer E, Bellows D, Kamberi M.   +8 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Liquid-based genomic profiling in high-risk localized prostate cancer. [PDF]

Front Urol
Bettoni F, Coser EM, Dos Santos EX, Canteli ARA, Morandi Filho R, Lira V, Loureiro L, Dellamano M, Torrieri R, Alves MJF, Cardili L, Muniz DQB, Ilário ÉN, Chammas R, Nahas WC, Bastos DA, Camargo AA.   +16 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source