Results 211 to 220 of about 5,008,337 (326)

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

Proceedings of the National Academy of Sciences of the United States of America, 2001
Arindam Bhattacharjee, William G. Richards, J. Staunton, Cheng Li, Stefano Monti, Priya Vasa, C. Ladd, J. Beheshti, Raphael Bueno, Michael A. Gillette, Massimo Loda, G. Weber, E. J. Mark, Eric S. Lander, W. Wong, B. E. Johnson, Todd R. Golub, D. Sugarbaker, M. Meyerson   +18 more
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Deciphering the blueprint of life: integrated protocols for single-cell multi-omics and functional genomics. [PDF]

Blood Sci
Hao S, Chen C.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparative analysis of ctDNA monitoring strategies in advanced NSCLC with MET exon 14 skipping mutations treated with ensartinib. [PDF]

NPJ Precis Oncol
Zhou M, Zhu Y, Sun X, Han Y, Jin R, Tian P, Zhao J, Jin Y, Guo Z, Zhang Y, Meng Y, Liu F, Li W, Le X, Shen H, Xia Y.   +15 more
europepmc   +1 more source

Spatially resolved, highly multiplexed RNA profiling in single cells

Science, 2015
Kok Hao Chen, A. Boettiger, J. Moffitt, Siyuan S Wang, X. Zhuang   +4 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Cellular Context Influences Kinase Inhibitor Selectivity. [PDF]

J Med Chem
Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD.   +7 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Next-generation liquid biopsies: detecting circulating epigenetic changes to identify translocation renal cell carcinoma. [PDF]

J Clin Invest
Ito K, Braun DA.
europepmc   +1 more source