Results 231 to 240 of about 5,008,337 (326)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An Audit of Accessibility and Actionability of Molecular Profiling for Patients with Cancer of Unknown Primary at a Tertiary Care Centre. [PDF]

Clin Pract
Abdulalem K, Teich J, Martinez E, Saibil SD.   +3 more
europepmc   +1 more source

MetaPhlAn2 for enhanced metagenomic taxonomic profiling

Nature Methods, 2015
Duy Tin Truong, E. Franzosa, Timothy L. Tickle, Matthias Scholz, G. Weingart, Edoardo Pasolli, Adrian Tett, C. Huttenhower, N. Segata   +8 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Genomic Therapy Matching in Rare and Refractory Cancers.

JAMA Oncol
Lin FP, Thavaneswaran S, Grady JP, Napier CE, Kansara M, Sebastian L, Kee D, Desai J, Zaheed M, Chinchen S, Oakes SR, Blackburn J, Scott HS, Glover A, Fox SB, Goldstein D, Leo P, Amanuel B, Mersiades A, Millward M, Brown MP, Charakidis M, Pokorny AMJ, Craft P, Espinoza D, Grimison P, Harrup R, Joshua AM, O'Byrne K, Lee CK, Cowley MJ, Ballinger ML, Simes J, Thomas DM, Australian Molecular Screening and Therapeutic program investigators and contributors .   +34 more
europepmc   +1 more source

Application of user profiling in mental health management: a scoping review. [PDF]

BMC Psychol
Fu C, Zhang Y, Huang X, Zhou J, Hu Y.
europepmc   +1 more source

Editorial Profiles [PDF]

Clinical & Experimental Ophthalmology, 2016
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Detection of Copy-Number Variations in CNS Tumours From Off-Target Reads of Hybrid-Capture Sequencing. [PDF]

Neuropathol Appl Neurobiol
Schnorrenberg J, Adrian YL, Schlathölter J, Ruckert C, Horvath J, Paulus W, Hasselblatt M, Thomas C.   +7 more
europepmc   +1 more source

Profile Summary

Drugs in R & D, 2002
openaire   +2 more sources