Results 41 to 50 of about 704,038 (263)

3D conformation and crystal interaction insights into drug development challenges for HCV drug analogues via molecular simulations

Communications Chemistry
ABT-333 and ABT-072 are two potent non-nucleoside NS5B polymerase inhibitors designed for the treatment of the hepatitis C virus (HCV). These structural analogs differ only by a minor substituent change, which disrupts the planarity of the naphthyl group
Richard S. Hong, Alessandra Mattei, Mark E. Tuckerman, Ahmad Y. Sheikh   +3 more
doaj   +1 more source

Performance Estimation of High-Level Dataflow Program on Heterogeneous Platforms by Dynamic Network Execution

Journal of Low Power Electronics and Applications, 2022
The performance of programs executed on heterogeneous parallel platforms largely depends on the design choices regarding how to partition the processing on the various different processing units.
Aurelien Bloch, Simone Casale-Brunet, Marco Mattavelli   +2 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

WNT inhibition activates interferon stimulated gene expression by alleviating epigenetic repression of endogenous retroviruses

Scientific Reports
As the use of immune checkpoint inhibitors for the treatment of cancer has expanded, convincing data have emerged correlating active WNT signaling with resistance to immunotherapies.
Courtney M. Williams, Jessica Harper Calderon, Varenka Rodriguez DiBlasi, Louis Jinrui Liu, Samer Nuwayhid, Hannah Cevasco, Wei Wang, Rekha Soni, Christina Adler, David D’Ambrosio, Namita T. Gupta, Christopher Daly   +11 more
doaj   +1 more source

Optimizing Numerical Weather Prediction Model Performance Using Machine Learning Techniques

IEEE Access, 2023
Weather forecasting primarily uses numerical weather prediction models that use weather observation data, including temperature and humidity, to predict future weather.
Soohyuck Choi, Eun-Sung Jung
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

The Chemical Fingerprint of Smokeless Powders: Insights from Headspace Odor Volatiles

Powders
Smokeless powders are a commonly used low explosive within the ammunition industry. Their ease of purchase has allowed criminals to use these products to build improvised explosive devices.
Miller N. Rangel, Andrea Celeste Medrano, Haylie Browning, Shawna F. Gallegos, Sarah A. Kane, Nathaniel J. Hall, Paola A. Prada-Tiedemann   +6 more
doaj   +1 more source

Instrumental intelligent platforms for criminal analysis

Law and Safety, 2021
The aim of the work is a comparative analysis of the most well-known foreign and domestic intelligent data mining platforms for criminal analysis. The relevance of this work is due to the peculiarities of the Fourth Industrial Revolution, the processes ...
V. M. Strukov, Y. V. Gnusov, Y. V. Gnusov   +2 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

Cancer Medicine, 2018
Esophageal cancer is one of the most common cancers and a leading cause of cancer‐related death worldwide. However, the mechanism of esophageal cancer pathogenesis remains poorly understood.
Wenjia Liu, Yiyang Zhang, Min Chen, Liangliang Shi, Lei Xu, Xiaoping Zou   +5 more
doaj   +1 more source