Results 171 to 180 of about 3,619,354 (396)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Changing Hospital Industry: Comparing For-Profit and Not-for-Profit Institutions [PDF]
David S. Salkever, Richard Frank
core +15 more sources
A imigração paraguaia contemporânea: elementos para a sua compreensão
REMHU: Revista Interdisciplinar da Mobilidade HumanaAlena Profit
doaj +1 more source
STRATEGIC PROFIT SHARING BETWEEN FIRMS: A WIN-WIN STRATEGY [PDF]
Our companion article developed a clear conceptual framework of profit sharing between two rival firms and studied the positive effects of this strategy on each firm's profit under the assumption that each firm decides unilaterally to give away ...
Roberts Waddle
core
Profits in poultry. Useful and ornamental breeds, and their profitable management
, 1888 T. M. Ferris +2 more
openalex +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Constraints on profit income distribution and production efficiency in private ownership economies with Ramsey taxation [PDF]
In economies with Ramsey taxation, decreasing returns to scale, and private ownership, we show that second-best production efficiency is desirable when profit tax rates vary across groups of firms provided that the institutional rules which define profit
Sushama Murty
core
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source