Results 91 to 100 of about 68,093 (293)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Energy Reports, 2019 A combined heat and power plant with regenerative closed-cycle gas turbine is considered. The heat transfer losses, irreversible adiabatic losses and irreversible pressure drop losses are considered in the plant.
Huijun Feng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Cost and Profit Efficiency of Kenyan Banks
, 2014 MBA thesisThis study investigates the cost and profit efficiency of Kenyan banks. This study uses published financial information to carry out stochastic frontier analysis, an econometric technique, to determine if there has been any change in the ...
Ayeyemi, Omowunmi Morayo
core
Profit Sharing and Efficiency in Utility Games.
, 2017 We study utility games (Vetta, FOCS 2002) where a set of players join teams to produce social utility, and receive individual utility in the form of payments in return. These games have many natural applications in competitive settings such as labor markets, crowdsourcing, etc. The efficiency of such a game depends on the profit sharing mechanism - the
Sreenivas Gollapudi +3 more
openaire +3 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The impact of internal and external factors on profit efficiency of islamic banks in Malaysia [PDF]
, 2021 The sustainability of the banking system depends on the profit efficiency of the banks. The profit efficiency of Islamic banks in Malaysia shows a fluctuating trend from the period of 2014 to 2018.
Siti Maizatul Shima, Yusoff
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Efficiency and Foreign Ownership in Banking: An International Comparison [PDF]
This paper estimates cost and profit efficiency for Latin American and the Caribbean banking sectors. This study also conducts a comparative analysis of the performance of foreign and domestic banks operating in these counties.
Saadet Kirbas Kasman +2 more
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