Results 171 to 180 of about 2,125,308 (306)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Mapping global oral health financing architectures: a scoping review protocol. [PDF]

BMJ Open
S D, Karuveettil V, Janakiram C, Ramanarayanan V, John D, Mini M, Green H.   +6 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Housing tenure, climate resilience, and ecological segregation. [PDF]

Proc Natl Acad Sci U S A
Gulsrud NM, Garcia-Antúnez O, Olafsson AS, Jensen MB.   +3 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Factors Influencing Profit Sharing Financing in Islamic Rural Bank: Evidence from Indonesia

This study aims to examine the impact of several financial indicators, namely return on assets (ROA), capital adequacy ratio (CAR), financing to deposit ratio (FDR), non-performing financing (NPF), and operational efficiency ratio (OER), on profit ...
Maulana, Agus, Fitria, Asyifa Zahrah
core   +1 more source

Global challenges and perspectives in acute and emergency general surgery in low and middle-income countries: a scoping review. [PDF]

BMJ Glob Health
Hindawi MD, Isik A, Rosa F, Visconti D, Nechay T, Chowdhury S, Ndong A, Mishra TS, Cioffi SPB, Kalmoush AE, Piscioneri F, Biffl WL, Tan ECTH.   +12 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Learning from Nigeria's public-private pathways to generate inclusive healthcare data. [PDF]

Commun Med (Lond)
Shrestha YR, Erden Z, Isik Ö, Demmel K, Tsevas S, Oluwadara O, McAvoy S, Descombes J, Rubio A.   +8 more
europepmc   +1 more source