Results 71 to 80 of about 261,536 (348)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Pengaruh Rasio Profitabilitas, Ukuran Perusahaan, Nilai Perusahaan, Dan Financial Leverage Terhadap Praktek Perataan Laba [PDF]

, 2013
This study aimed to examine the effect of profitability ratios, firm size, firm value and financial leverage on income smoothing practices. Income smoothing is one pattern of earnings management.
Defrianto, Romaldus Senja
core  

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

An Examination of Relationship between Labor and Capital Indexes with Profitability Indexes in Public Companies [PDF]

مطالعات تجربی حسابداری مالی, 2003
The aim of this research is to find any relationship between productivity and profitability indexes; the fact that whether productivity level movement affects the profit movement or not? And if there is any relationship between them, how is it?
Hassan Ali Sinaei, Farzad Ahmadi
doaj  

Overall profit Malmquist productivity index under data uncertainty [PDF]

Financial Innovation, 2020
AbstractThe calculation of the overall profit Malmquist productivity index (MPI) requires precise and accurate information on the input, output, input-output prices of each decision making unit (DMU). However, in many situations, some inputs and/or outputs and input-output prices are imprecise.
openaire   +4 more sources

Expert consensus on research paradigms and technological layout for clinical priority diseases in traditional Chinese medicine: Rheumatoid arthritis

Advanced Chinese Medicine, EarlyView.
Abstract Rheumatoid arthritis (RA) is a chronic, highly disabling autoimmune disease. Although modern medical treatments have made progress, challenges such as suboptimal efficacy, relapse, difficulties in comorbidity management, and side effects persist.
Dier Jin, Jinping Wang, Zihan Wang, Mei Mo, Xiaojing Liu, Nan Zhang, Xiaoxiao Zhang, Qingwen Tao, Yuan Xu   +8 more
wiley   +1 more source

Prophylactic Management of Vestibular Migraine: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Vestibular migraine (VM) is a neurological disorder characterized by episodic vertigo in patients with migraine, contributing to substantial functional impairment. Although VM is relatively common, a consensus on effective prophylactic treatments is lacking.
Hussain Ali Almohammed, Husna Irfan Thalib, Kawthar Faisal Kushara, Bushra Wadi Bin Saddiq, Bayan Mohammed Khair Al Zoabi, Tanveer Nidal Khan, Ahmed Salah Morad, Rimas Warid Aljuaid, Lamyaa Mohammed Gharawi, Shahad Jawdat Alsaygh, Mable Pereira, Shaima Abuhulayqah   +11 more
wiley   +1 more source

Economic efficiency assessment of investment [PDF]

Anali Ekonomskog fakulteta u Subotici, 2018
The aim of the paper is to determine economic reasonableness of investments based on several methods of capital budgeting. The research was conducted on the example of purchasing 10 hectares of land that will be used for agricultural production of corn ...
Vlaović-Begović Sanja, Momčilović Mirela, Tomašević Stevan   +2 more
doaj  

Considerations for Issues of Regression to the Mean and Contextual Effects in Clinical Trials for Pain in Rheumatic Diseases

Arthritis Care &Research, EarlyView.
Recently, there has been growing discussion about how to best assess pain in clinical trials in rheumatic diseases. Reliable measurement of pain outcomes is essential for accurately determining the effectiveness of treatments. Although pain intensity is the most common measure of change in pain trials, other pain‐related measures, such as pain ...
Yen T. Chen, Guohao Zhu, Afton L. Hassett, Daniel Clauw, Susan L. Murphy   +4 more
wiley   +1 more source

The Profitability in the FTSE 100 Index: A New Markov Chain Approach

Asia-Pacific Financial Markets, 2019
In this paper, we propose a new method to predict stock market trends based on the multivariate Markov chain (MMC) methodology. Our approach consists of forecasting the one-period ahead FTSE 100 Index behavior, using the MTD-Probit model. The MTD-Probit model is a new approach for estimating MMC, based on multiple categorical data sequences that can be
Flavio Ivo Riedlinger, João Nicolau
openaire   +3 more sources