Results 111 to 120 of about 35,778 (253)

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Estimativa do número apropriado de progênies S1 para a seleção recorrente em milho

Pesquisa Agropecuária Brasileira, 2000
O objetivo deste trabalho foi determinar o número desejável de progênies S1 para avaliação em programas de seleção recorrente em milho (Zea mays L.). Foram avaliadas, em blocos casualizados, em dois locais e três repetições por local, 200 progênies das ...
Pinto Rogério de Melo Costa, Lima Neto Francisco Pinheiro, Souza Júnior Cláudio Lopes de   +2 more
doaj  

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Sexto ciclo de seleção recorrente fenotípica visando resistência à mancha-angular no feijoeiro. [PDF]

, 2013
Neste trabalho são apresentados os resultados obtidos na avaliação de progênies do sexto ciclo de seleção do referido ...
ABREU, A. de F. B., ARANTES, L. de O., NEVES, A. F. das, RAMALHO, M. A. P.   +3 more
core  

Seeds of change: The impact of Ethiopia's direct seed marketing approach on smallholders' seed purchases and productivity

American Journal of Agricultural Economics, EarlyView.
Abstract While multiple factors explain low adoption rates of improved varieties by small‐scale farmers in sub‐Saharan Africa, a key supply‐side constraint is the limited availability of seed embodying new traits in the volume, quality, price, and timeliness required by farmers. This constraint is partly attributable to classical failures in the market
Dawit Mekonnen, Gashaw T. Abate, Seid Yimam, Rui Benfica, David J. Spielman, Frank Place   +5 more
wiley   +1 more source

Melhoramento do feijoeiro de grãos tipo carioca para produtividade, arquitetura ereta da planta e resistência a patógenos. [PDF]

, 2012
Esse trabalho teve por objetivos obter linhagens de feijoeiro com boa produtividade, grãos tipo carioca, de porte ereto e resistentes aos fungos Colletotrichum lindemuthianum e Pseudocercospora griseola ...
ABREU, A. de F. B., LIMA, J. G., RAMALHO, M. A. P., SILVA, C. A.   +3 more
core  

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Interação de genótipos de Pinus taeda L. com locais no sul-sudeste do Brasil. [PDF]

, 2015
A importância da resposta relativa diferenciada de progênies e de árvores por locais em Pinus taeda L. na perda de potencial genético pela seleção foi estudada no caráter volume de madeira total do tronco, em 46 progênies de meio-irmãos, em quatro locais
MAESTRI, R., MORA, A. L., PALUDZYSZYN FILHO, E.   +2 more
core  

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source