Results 61 to 70 of about 24,050 (247)

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

POMAR DE SEMENTES POR MUDAS A PARTIR DA SELEÇÃO DENTRO EM TESTE DE PROGÊNIES DE Myracrodruon urundeuva Fr. All.

Revista do Instituto Florestal, 2007
A conservação genética de espécies arbóreas é fundamental para que as futuras gerações possam usufruir os recursos fornecidos atualmente por estas espécies.
Miguel Luiz Menezes Freitas, Alexandre Magno Sebbenn, Antonio Carlos Scatena Zanatto, Eurípedes Moraes   +3 more
doaj   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Segregation of powdery mildew (Podosphaera leucotricha [Ell. et Ev. /Salm./]) resistance within 54 apple progenies

Horticultural Science, 2004
The occurrence of powdery mildew after heavy spontaneous infections was evaluated on 2,500 apple seedlings of 54 progenies that were derived from crosses made in 1993 and 1994. At the same time, the response to mildew was also assessed on 47 cultivars or
J. Blažek, J. Křelinová, H. Drahošová   +2 more
doaj   +1 more source

Heuristically Adaptive Diffusion‐Model Evolutionary Strategy

Advanced Science, EarlyView.
Building on the mathematical equivalence between diffusion models and evolutionary algorithms, researchers demonstrate unprecedented control over evolutionary optimization through conditional diffusion. By training diffusion models to associate parameters with specific traits, they can guide evolution toward solutions exhibiting desired behaviors ...
Benedikt Hartl, Yanbo Zhang, Hananel Hazan, Michael Levin   +3 more
wiley   +1 more source

ARTICLE - Inbreeding depression in castor bean (Ricinus communis L.) progenies [PDF]

Crop Breeding and Applied Biotechnology, 2012
The purpose of this study was to investigate inbreeding depression (DE) in castor bean. From a population derived from the Guarani cultivar, 60 mother plants were sampled.
Milton Krieger, Roland Vencovsky, Inocencio Junior de Oliveira, Maurício Dutra Zanotto   +3 more
doaj  

Variação genética em progênies de Myracrodruon urundeuva F.F. & M.F. Allemão em três sistemas de cultivo Genetic variation in progenies of Myracrodruon urundeuva F.F. & M.F. Allemao in three cultivation systems

Revista Árvore, 2006
Myracrodruon urundeuva (aroeira) é uma das espécies arbóreas que apresentam madeira de maior durabilidade em contato com o solo. Em razão dessa característica, populações naturais de M. urundeuva, distribuídas por quase todo o Brasil, vêm sendo dizimadas.
Miguel Luiz Menezes Freitas, Ana Paula de Andrade Aukar, Alexandre Magno Sebbenn, Mario Luiz Teixeira de Moraes, Eliana Gertrudes Macedo Lemos   +4 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

ALTAS HERDABILIDADES E GANHOS NA SELEÇÃO PARA CARACTERES DE CRESCIMENTO EM TESTE DE PROGÊNIES DE POLINIZAÇÃO ABERTA DE Pinus elliottii Engelm var. elliottii, AOS 25 ANOS DE IDADE EM ASSIS−SP

Revista do Instituto Florestal, 2008
O objetivo deste trabalho foi estimar parâmetros genéticos para caracteres de crescimento em teste de progênies de polinização aberta de Pinus elliottii Engelm var. elliottii, aos 25 anos de idade em Assis−SP.
Alexandre Magno Sebbenn, Osmar Vilas Bôas, José Carlos Molina Max   +2 more
doaj   +1 more source