Results 131 to 140 of about 551,564 (339)

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

Ni‐Catalyzed Electrochemical Carbonylative Ketone Synthesis Employing a Radical Sorting Strategy

Angewandte Chemie, EarlyView.
An electrolytic‐Ni‐catalyzed general synthesis of ketones was reported, utilizing radicals and carbon monoxide as partners. The radical sorting effect was proposed within an outer sphere addition mechanism of alkyl radicals to Ni‐stabilized ketyl radicals, thereby facilitating selectivity among different radicals. This protocol allows for a broad range
Jinkun Fan, Hao Sun, Yukai Wang, Xu Cheng   +3 more
wiley   +2 more sources

Effects of progesterone on hypoxia-induced inhibition of excitatory synaptic transmission in the rat nucleus tractus solitarius

Journal of Pharmacological Sciences, 2019
The present study evaluated the ability of progesterone to alleviate the synaptic transmission disturbed by hypoxia in the nucleus tractus solitarius (NTS).
Yoshiaki Ohi, Daisuke Kodama, Akira Haji
doaj   +1 more source

Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies [PDF]

, 2018
Yinhao Wu, W. McIntyre Burnham
openalex   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]

, 2016
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector, Ghini, Alberto Antonio, Rey, Mariana   +2 more
core   +1 more source

Current status of estrogen and progesterone receptors in breast cancer [PDF]

, 1977
William McGuire, Kathryn B. Horwitz, Olof H. Pearson, A Segaloff   +3 more
openalex   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids

BMC Women's Health, 2019
Background Uterine Fibroids (UFs) growth is ovarian steroid-dependent. Previous studies have shown that estrogen and progesterone play an important role in UF development.
Mona Omar, Archana Laknaur, Ayman Al-Hendy, Qiwei Yang   +3 more
doaj   +1 more source