Results 131 to 140 of about 558,932 (378)

Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial [PDF]

, 2015
Amelie van der Ven, C. Emily Kleinrouweler, Ewoud Schuit, Brenda M. Kazemier, Corine Verhoeven, Esteriek de Miranda, Aleid G. Leemhuis, J. Sikkema, Mallory Woiski, Patrick Bossuyt, Eva Pajkrt, Christianne J.M. de Groot, Ben Willem Mol, Monique C. Haak, Melanie van Os   +14 more
openalex   +1 more source

Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins [PDF]

, 2000
PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and
Aguilar, A, Borrell, A, Haraguchi, K, Mattson, M, Siebert, U, Troisi, GM   +5 more
core  

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Effects of progesterone on hypoxia-induced inhibition of excitatory synaptic transmission in the rat nucleus tractus solitarius

Journal of Pharmacological Sciences, 2019
The present study evaluated the ability of progesterone to alleviate the synaptic transmission disturbed by hypoxia in the nucleus tractus solitarius (NTS).
Yoshiaki Ohi, Daisuke Kodama, Akira Haji
doaj   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source

Evidence that a GABAA-Like Receptor is Involved in Progesterone-Induced Acrosomal Exocytosis in Mouse Spermatozoa1 [PDF]

, 1995
Qi‐Xian Shi, Eduardo R. S. Roldán
openalex   +1 more source

Progesterone promotes maternal–fetal tolerance by reducing human maternal T‐cell polyfunctionality and inducing a specific cytokine profile

European Journal of Immunology, 2015
Progesterone is a steroid hormone essential for the maintenance of human pregnancy, and its actions are thought to include promoting maternal immune tolerance of the semiallogenic fetus.
D. Lissauer, S. Eldershaw, C. Inman, A. Coomarasamy, P. Moss, M. Kilby   +5 more
semanticscholar   +1 more source

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids

BMC Women's Health, 2019
Background Uterine Fibroids (UFs) growth is ovarian steroid-dependent. Previous studies have shown that estrogen and progesterone play an important role in UF development.
Mona Omar, Archana Laknaur, Ayman Al-Hendy, Qiwei Yang   +3 more
doaj   +1 more source

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Journal of Neuroinflammation, 2015
Repeated mild traumatic brain injuries, such as concussions, may result in cumulative brain damage, neurodegeneration and other chronic neurological impairments.
Kyria M. Webster, David K. Wright, Mujun Sun, B. Semple, E. Ozturk, D. Stein, T. O’Brien, S. Shultz   +7 more
semanticscholar   +1 more source