Results 231 to 240 of about 363,488 (344)

Long‐term child outcomes after prenatal aspirin exposure: A 4‐year follow‐up of a randomized controlled trial (the APRIL study)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify the long‐term child outcomes after prenatal aspirin exposure. Methods This study is a follow‐up of a randomized controlled trial (RCT) evaluating low‐dose aspirin in the prevention of recurrent spontaneous preterm labor (the APRIL study) comparing aspirin 80 mg daily (n = 194) to placebo (n = 193) in singletons.
Emilie V. J. van Limburg Stirum, Janneke van ’t Hooft, Anadeijda J. E. M. C. Landman, Martijn J. J. Finken, Anita C. J. Ravelli, Aleid G. Leemhuis, Eva Pajkrt, Martijn A. Oudijk, Marjon A. de Boer   +8 more
wiley   +1 more source

Elevated serum estradiol levels on embryo transfer day predict higher pregnancy success in HRT-FET cycles. [PDF]

Reprod Biol Endocrinol
Kutenaee MA, Bahmani F, Fesahat F, Roozbeh N, Salehi E.   +4 more
europepmc   +1 more source

An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data

iMetaMed, EarlyView.
This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5‐year survival in breast cancer. The optimal predictive model with 13 key predictors demonstrated excellent predictive performance with strong accuracy, precision, and F1.
Zhixuan Wu, Shengnan Yao, Lingli Jin, Xue Wu, Rongrong Zhang, Ouchen Wang, Erjie Xia   +6 more
wiley   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

The Journal of Clinical Pharmacology, EarlyView.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun, Huili Chen, Brian Cicali, Serge Guzy, Joachim Hoechel, Tianze Jiao, Valvanera Vozmediano, Stephan Schmidt   +7 more
wiley   +1 more source

Preoperative multiparametric magnetic resonance imaging and contrast‐enhanced mammography radiomics based nonsentinel lymph node metastasis prediction in breast cancer

Journal of Intelligent Medicine, EarlyView.
Abstract Models based on magnetic resonance imaging (MRI) and contrast‐enhanced mammography (CEM) radiomics for noninvasive prediction of nonsentinel lymph node (NSLN) metastasis were developed in this study. A total of 270 patients who had undergone axillary lymph node dissection from January 2018 to October 2022 and were diagnosed with 1–2 positive ...
Wei Jiang, Xiaopeng Wang, Yu Guo, Qiping Yang, Yuhong Du, Ning Zhang, Yuanyuan Chen, QiuYun Fan   +7 more
wiley   +1 more source

Estrogen and Progesterone Exhibit Distinct Yet Coordinated Roles in the Regulation of Tendon Extracellular Matrix Remodeling

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Remodeling of the extracellular matrix (ECM) is required for the proper healing, strengthening, and maintenance of tendon tissue. There are well‐documented sex differences in tendon injury rates and healing outcomes, often attributed to either innate differences in tissue structure and resident cell signaling or the influence of sex hormones ...
Allison M. Sander, Brianne K. Connizzo
wiley   +1 more source

Sulfiredoxin stimulates luteinization in vitro by promoting progesterone production in rats. [PDF]

Reproduction
Chun SY, Park EH, Jang M, Park JI, Jang YJ.   +4 more
europepmc   +1 more source

Progesterone and the risk of preterm birth among women with a short cervix.

New England Journal of Medicine, 2007
E. Fonseca, E. Çelik, M. Parra, Mandeep Singh, K. Nicolaides   +4 more
semanticscholar   +1 more source

Adrenal secretion rates and adrenal tissue concentrations of pregnenolone, progesterone, 11βOH‐androstenedione and some other steroids in young pigs and dogs

, 1969
Margarethe Holzbauer, Helen M. Newport
openalex   +2 more sources