Results 111 to 120 of about 2,330 (251)
Comparison of Transcriptional Activation by Corticosteroids of Human MR (Ile-180) and Human MR Haplotype (Ile180Val) [PDF]
arXivWhile the classical function of human mineralocorticoid receptor (MR) is to regulate sodium and potassium homeostasis through aldosterone activation of the kidney MR, the MR also is highly expressed in the brain, where the MR is activated by cortisol in response to stress. Here, we report the half-maximal response (EC50) and fold-activation by cortisol,
arxiv
Andrology, EarlyView.Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert +10 more
wiley +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]
arXivDuring cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv
Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 591-603, April 2025.We found a strong time‐dependent, inverse association between the use of oral contraceptives and the odds of having endometrial cancer. According to our results, the longer women were exposed to oral contraceptives, the greater the odds reduction of endometrial cancer was.
András Harajka +14 more
wiley +1 more source
The Effect of Progestins on Cytokine Production in the Peripheral Blood Mononuclear Cells of Menopausal Women and Their Luminol-Dependent Chemiluminescence. [PDF]
Molecules, 2023 Pavlik TI +3 more
europepmc +1 more source
Toxicological profile for chlorodibenzofurans (CDFs) [PDF]
VERSION HISTORYDate DescriptionApril 2023 Final toxicological profile releasedJanuary 2022 Draft for public comment toxicological profile releasedMay 1994 Final toxicological profile releasedtp32 ...
core
Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 755-762, April 2025.Ultrasound‐guided percutaneous microwave ablation of abdominal wall endometriosis is safe and effective, and it is safer when combined with single‐port laparoscopy monitoring in the case of deep lesions. Abstract Introduction Raising the temperature of abdominal wall endometriosis lesions contributes to an effective ablation; however, providing ...
Shunshi Yang +7 more
wiley +1 more source
The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation. [PDF]
Toxicol Appl Pharmacol, 2022 Pu Y +4 more
europepmc +1 more source
Efficacy of transabdominal cerclage by open laparotomy relative to existing risk factors
Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 685-696, April 2025.Transabdominal cerclage via open laparotomy relates to 92% survival, gestational age at delivery of 37.3 weeks, with 92% of deliveries ≥34 weeks. Despite existing risk factors, outcomes are similar, and independent of cervical length before transabdominal cerclage or between transabdominal cerclage and external os.
Cecile C. Hulshoff +3 more
wiley +1 more source