Results 121 to 130 of about 2,330 (251)

Seasonal patterns of preterm birth in the Netherlands: A population‐based cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In the Netherlands, the incidence of preterm birth in singletons is subject to seasonal periodicity. Conception in April and May is associated with the highest risk of preterm birth. Fetuses are at the highest risk for preterm birth from October to January and at the lowest risk in February and April.
Annabelle L. van Gils, Anita C. Ravelli, Brenda M. Kazemier, Eva Pajkrt, Martijn A. Oudijk   +4 more
wiley   +1 more source

Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats. [PDF]

PLoS One, 2023
Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Takiguchi M, Tanabe S, Ishizuka M.   +9 more
europepmc   +1 more source

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex

Brain Pathology, Volume 35, Issue 3, May 2025.
This study analyzes four public transcriptome datasets from AD patients and age‐matched controls, revealing that the transcriptomic profile in female controls closely resembles that of AD patients. We identified a co‐expressed gene module associated with AD, sex, and aging, enriched with immune‐related functions.
Huiying Wen, Youzhe He, Yuanchun Tang, Langjian Zhu, Quyuan Tao, Bufan Jin, Ting Luo, Yujie Peng, Yanrong Wei, Junjie Lei, Lifang Wang, Fan Wang, Fei Ling, Yue Gao, Lei Han   +14 more
wiley   +1 more source

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview. [PDF]

Animals (Basel), 2023
Pocar P, Grieco V, Aidos L, Borromeo V.
europepmc   +1 more source

Susceptibility of Brca1(L63X/+) rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer

Cancer Science, Volume 116, Issue 4, Page 1139-1152, April 2025.
We analyzed the effects of olaparib in the presence and absence of cyclophosphamide in a recently established rat BRCA1‐mutant model and found for the first time that mutant ovaries are more susceptible to oxidative stress, potentially depleting primordial follicles via activation of granulosa cells and inducing oocyte death due to accumulated DNA ...
Satoshi Kaseki, Reina Sonehara, Yashiro Motooka, Hideaki Tanaka, Tomoko Nakamura, Satoko Osuka, Shinya Akatsuka, Hiroaki Kajiyama, Tomoji Mashimo, Tatsuhiko Imaoka, Shinya Toyokuni   +10 more
wiley   +1 more source

Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer

Cancer Science, Volume 116, Issue 4, Page 1048-1058, April 2025.
This study included 7278 Asian patients and revealed that those carrying BRCA1/2 pathogenic variants had significantly shorter 10‐year invasive disease‐free survival and relapse‐free survival than noncarriers. No significant difference in survival was observed in patients with non‐BRCA1/2 pathogenic variants.
Rui Kitadai, Shu Yazaki, Aya Kuchiba, Takashi Yamanaka, Sho Shiino, Chisako Yamauchi, Kenichi Harano, Motonobu Saito, Yosuke Hirotsu, Hisaki Aiba, Teruhiko Yoshida, Ryuji Hamamoto, Chikako Shimizu, Akihiko Shimomura, Yuki Kojima, Tatsunori Shimoi, Yukihide Momozawa, Kazuki Sudo, Masayuki Yoshida, Kuniko Sunami, Megumi Hori, Kota Katanoda, Yoko Shimada, Yuji Yamashita, Takahiro Kogawa, Takeshi Murata, Saori Fujiwara, Yohei Miyagi, Hiroshi Nakagomi, Kazunoshin Tachibana, Masao Omata, Tohru Ohtake, Akihiko Suto, Tatsuya Onishi, Yoichi Naito, Toshinari Yamashita, Kan Yonemori, Takashi Kohno, Kouya Shiraishi   +38 more
wiley   +1 more source

The Time Lag Associated With the Reclassification of Germline BRCA Variants' Pathogenicity Is Critical for Cancer Patients

Cancer Science, EarlyView.
The period for reclassifying the variants' pathogenicity is too long for patients with advanced or recurrent cancers with variants of uncertain significance that can be objectively re‐evaluated to be (likely) pathogenic according to accumulated evidence.
Tomomi Hayashi, Hiroyuki Matsubayashi, Yoshimi Kiyozumi   +2 more
wiley   +1 more source

Comparative Net Survival Analysis of Men and Women With Breast Cancer in Japan: A Population‐Based Study

Cancer Science, EarlyView.
This study compared male breast cancer (MBC) and female breast cancer (FBC) survival using data from Japanese population‐based cancer registries diagnosed between 1993 and 2011. The findings reveal that MBC survival is comparable to FBC, with no significant sex‐based differences in 5‐ and 10‐year net survival across period, age, stage, and histological
Daisy Sibale Mojoo, Isao Oze, Hiroshi Tsuge, Yukari Taniyama, Yuriko N. Koyanagi, Sayaka Yamamoto, Megumi Hori, Kayo Nakata, Hiromi Sugiyama, Isao Miyashiro, Izumi Oki, Yoshikazu Nishino, Yuri Ito, Kota Katanoda, Akiko Shibata, Tomohiro Matsuda, Keitaro Matsuo, Hidemi Ito   +17 more
wiley   +1 more source

The transcriptional activity of progestins used in contraception and menopausal hormone therapy via progesterone receptor A is dependent on the density of the receptor. [PDF]

Biochem Biophys Res Commun, 2023
Cartwright M, Toit RL, Africander D.
europepmc   +1 more source

OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells

Cancer Science, EarlyView.
The transcription factor OCT‐2 (encoded by POU2F2) is involved in the formation of super‐enhancers (SEs) in triple‐negative breast cancer (TNBC) cells. Overexpression of POU2F2 enhances the metastasis of TNBC cells in mice, and their expression is highly correlated to the poor prognosis of TNBC patients. ABSTRACT Triple‐negative breast cancer (TNBC) is
Kazuki Ogikubo, Jun Nishida, Kei Takahashi‐Yamashiro, Masato Morikawa, Shogo Ehata, Tetsuro Watabe, Kohei Miyazono, Daizo Koinuma   +7 more
wiley   +1 more source