Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley +1 more source
ABSTRACT Objective Sleep problems like obstructive sleep apnea (OSA) are common in polycystic ovary syndrome (PCOS), although the underlying mechanisms are not well understood. We aimed to determine the prevalence of sleep problems, synthesise and appraise studies analysing the associations between serum sex hormones, sex hormone‐binding globulin (SHBG)
Nur K. Abdul Jafar+4 more
wiley +1 more source
Neurotransmitter Systems Affected by PBDE Exposure: Insights from In Vivo and In Vitro Neurotoxicity Studies. [PDF]
García-Suastegui WA+6 more
europepmc +1 more source
BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis. [PDF]
Casella M+4 more
europepmc +1 more source
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan+14 more
wiley +1 more source
QSTR Models in Dioxins and Dioxin-like Compounds Provide Insights into Gene Expression Dysregulation. [PDF]
Eleazar EG+4 more
europepmc +1 more source
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang+17 more
wiley +1 more source
Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging
Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi+6 more
wiley +1 more source
Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review. [PDF]
Hansel MC+5 more
europepmc +1 more source