Results 21 to 30 of about 2,330 (251)

Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero [PDF]

, 2007
BACKGROUND. Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the mid-1900s, is a potent endocrine disruptor. Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ...
Arthur L. Herbst, Bernstein L, Bibbo M, Breslow NE, Dorgan JF, Elizabeth E. Hatch, Horne HW, Julie R. Palmer, Kaufman RH, Kenneth L. Noller, Lauren A. Wise, Linda Titus-Ernstoff, Raymond Kaufman, Rebecca Troisi, Robert N. Hoover, Sadler TW, SAS Institute Inc, Wu CH   +17 more
core   +3 more sources

In Vitro [PDF]

, 2002
In our previous paper[1], we demonstrated that porcine follicles collected during the early stage of development are the most sensitive to the toxic action of polychlorinated biphenyl 153 (PCB 153).
Anna K. Wjtówicz, Ewa L. Gregoraszczuk
core   +2 more sources

Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor [PDF]

arXiv, 2020
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of progesterone is its high affinity for the mineralocorticoid receptor (MR), which regulates electrolyte ...
arxiv  

Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain [PDF]

arXiv, 2021
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by ...
arxiv  

Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins [PDF]

, 2000
PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and
Aguilar, A, Borrell, A, Haraguchi, K, Mattson, M, Siebert, U, Troisi, GM   +5 more
core  

Endocrine-disrupting chemicals : some actions of POPs on female reproduction [PDF]

, 2013
Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic ...
Gregoraszczuk, Ewa, Ptak, Anna
core   +2 more sources

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Levels and enantiomeric signatures of methyl sulfonyl PCB and DDE metabolites in livers of harbor porpoises (Phocoena phocoena) from the southern North Sea [PDF]

, 2003
The concentration of 26 methyl sulfonyl metabolites of polychlorinated biphenyls (MeSO2-PCBs) and of p,p'-DDE (MeSO2-DDE) were determined in 19 liver samples from harbor porpoises (Phocoena phocoena) stranded between 1997 and 2000 on the Belgian and ...
Berggren P., Bergman, Boon J. P., Boon J. P., Boon J. P., Brandt I., Chu S. G., Chu S. G., Chu S. G., Covaci A., Ellerichmann T., Haraguchi K., Haraguchi K., Harner T., Hühnerfuss H., Hühnerfuss H., Jensen S., Kaiser K. L. E., Karlson K., Koake G., Larsen G. L., Larsson C., Letcher R. J., Letcher R. J., Letcher R. J., Nagayama J., Nezel T., Tanabe S., Troisi G. M., Troisi G. M., Weistrand C., Wiberg K.   +31 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis [PDF]

Molecular and Cellular Endocrinology, 436:10--22 (2016), 2018
Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation.
arxiv   +1 more source