Results 131 to 140 of about 2,759,065 (349)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Hydrogeochemical characteristics and significance of produced water from coalbed methane wells in Fukang Mining Area

Meikuang Anquan
In order to explore the hydrogeochemical characteristics of coal seam water produced in Fukang Mining Area, the recharge relationship between stagnant aquifer and coal seam water in the fire area and the water chemical evolution model, this study ...
Donglei JIA, Haichao WANG, Jijun TIAN, Daping XIA, Bo WANG, Qingcheng GONG   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Prognosis [PDF]

Otolaryngology–Head and Neck Surgery, 2013
openaire   +2 more sources

Classification and Personalized Prognosis in Myeloproliferative Neoplasms [PDF]

, 2018
Jacob Grinfeld, Jyoti Nangalia, E. Joanna Baxter, David C. Wedge, Nicos Angelopoulos, R. Cantrill, Anna L. Godfrey, Elli Papaemmanuil, Gunes Gundem, Cathy MacLean, Julia Cook, Laura O’Neil, Sarah O’Meara, Jon W. Teague, Adam P. Butler, Charlie E. Massie, Nicholas Williams, Francesca Nice, Christen Lykkegaard Andersen, Hans Carl Hasselbalch, Paola Guglielmelli, Mary Frances McMullin, Alessandro M. Vannucchi, Claire Harrison, Moritz Gerstung, Anthony R. Green, Peter J. Campbell   +26 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Optimal allocation of brackish groundwater in arid inland area: A case study

Guan'gai paishui xuebao
【Objective】Groundwater is a vital resource for agricultural irrigation in arid regions, but excessive exploitation has led to over-mineralization, making water unsuitable for direct use.
JIA Yifan, GE Yanyan, LI Sheng, JIE Feilong   +3 more
doaj   +1 more source

Prognosis of Women With Primary Breast Cancer Diagnosed During Pregnancy: Results From an International Collaborative Study [PDF]

, 2013
Frédéric Amant, Gϋnter von Minckwitz, Sileny Han, M. Bontenbal, Alistair Ring, Jerzy Giermek, Hans Wildiers, Tanja Fehm, Sabine C. Linn, B. Schlehe, Patrick Neven, Pieter J. Westenend, Volkmar Müller, Kristel Van Calsteren, Brigitte Rack, Valentina Nekljudova, Nadia Harbeck, Michael Untch, Petronella O. Witteveen, Kathrin Schwedler, Christoph Thomssen, Ben Van Calster, Sibylle Loibl   +22 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source