Results 131 to 140 of about 3,538,014 (404)

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

New England Journal of Medicine, 2018
BACKGROUND Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates.
J. Grinfeld, J. Nangalia, J. Baxter, D. Wedge, Nicos Angelopoulos, R. Cantrill, A. Godfrey, E. Papaemmanuil, G. Gundem, C. Maclean, J. Cook, Laura O'Neil, S. O’Meara, J. Teague, A. Butler, C. Massie, N. Williams, Francesca L. Nice, C. Andersen, H. Hasselbalch, P. Guglielmelli, M. McMullin, A. Vannucchi, C. Harrison, M. Gerstung, A. Green, P. Campbell   +26 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Grobner Bases for Nonlinear DAE Systems of Analog Circuits [PDF]

Computer Science Journal of Moldova, 2008
Systems of differential equations play an important role in modelling and analysis of many complex systems e.g. in electronics and mechanics. The following article is concerned with a symbolic analysis approach for reduction of the differential index of ...
Silke J. Spang
doaj  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Recent advances in understanding and managing psoriatic arthritis [version 1; referees: 2 approved]

F1000Research, 2016
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches.
Dafna D. Gladman
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

The Incidence and Prognosis of Endogenous Depression [PDF]

, 1956
C. A. H. Watts
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Enhanced Fatigue Crack Detection in Complex Structure with Large Cutout Using Nonlinear Lamb Wave

Sensors
The large cutout structure is a key component in the bottom skin of an airplane wing, and is susceptible to developing fatigue cracks under service loads.
Suofeng Zhang, Yuan Liu, Shenfang Yuan
doaj   +1 more source

THE DIAGNOSIS AND PROGNOSIS OF TUBERCULOSIS IN INFANCY [PDF]

, 1921
CHARLES HUNTER DUNN
openalex   +1 more source