Results 151 to 160 of about 5,348,587 (297)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CRP-Albumin-Lymphocyte (CALLY) Index Is an Independent Prognostic Factor for Recurrent Esophageal Cancer After Curative Treatment. [PDF]

In Vivo
Takagi M, Aoyama T, Hashimoto I, Kawabe T, Maezawa Y, Sato S, DEN K, Kosaka T, Sato T, Atsumi Y, Kayashima M, Sekiguchi K, Tamagawa A, Kazama K, Sugano N, Cho H, Yukawa N, Yoshikawa T.   +17 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer. [PDF]

J Pers Med
Gajewski F, Pec J, Kleinrok J, Pająk W, Pacyna K, Tokarzewska A, Krawczyk P.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Age as a significant prognostic factor in patients meeting the global ARDS definition but not the Berlin definition. [PDF]

Front Med (Lausanne)
Pan P, Chen J, Zhang T, Haibo C, Wanyi Z, Han X, Xinjie H, Xingshuo H, Qingyun Y, Hongjun G, Yuhong L, Xie L.   +11 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

AMSTAR-PF: a critical appraisal tool for systematic reviews of prognostic factor studies

The ability to predict the onset or natural history of an illness, or how people may respond to a treatment, guides clinical decision making. These predictions are commonly based on prognostic factors: clinical, patient, or societal variables that are ...
Shea, B.J., Moons, K.G.M., Riley, R.D., Hooft, L., Skoetz, N., Wallwork, S.B., Henry, M.L., Damen, J.A.A., O'Connell, N.E., Moseley, G.L.   +9 more
core   +1 more source