Results 161 to 170 of about 2,292,592 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Prognostic role of the Glasgow prognostic score and modified Glasgow prognostic score in patients with renal cell carcinoma undergoing immunotherapy: a meta-analysis. [PDF]

Clinics (Sao Paulo)
Zhang X, Li X, Xie Y, Shi N.
europepmc   +1 more source

Confounding adjustment using prognostic score methods

In a previous chapter, techniques for confounding adjustment using the propensity score have been presented. These methods rely on modeling the expected value (or probability) of the treatment given the confounding variables.
Nguyen, Tri Long, Debray, Thomas P.A.
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Glasgow Prognostic Score and Gustave Roussy Immune Score in Hodgkin Lymphoma: Survival Associations and Limited Incremental Prognostic Value Beyond the International Prognostic Score. [PDF]

J Clin Med
Aygün K, Solmaz Ş, Aygün O, Eryılmaz İ, Cetintepe T, Kiper Unal HD, Garip Acar A, Arslan E.   +7 more
europepmc   +1 more source

Clinical Implications of Naples Prognostic Score for Patients with Resected Cholangiocarcinoma: A Real-World Experience

Benjie Xu,* Jiahao Zhu,* Ren Wang, Xiangyi Pang, Xin Wang, Jie Lian, Haibo Lu Department of Outpatient Chemotherapy, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China*These authors contributed equally to this ...
Lian J, Zhu J, Wang R, Lu H, Xu B, Wang X, Pang X   +6 more
core  

Prognostic Impact of Conglomerated Cribriform Morphology in Gleason Score 7 Prostate Adenocarcinoma

Objective: Cribriform architecture has increasingly been recognized as an adverse morphological feature in prostate adenocarcinoma. The present study aimed to describe a novel histopathological subtype of cribriform architecture, termed conglomerated ...
Acikalin, Mustafa, ŞEKER, NAZLI SENA, Ata Özen, Ertuğrul Çolak, Yaldir, EMEL, Mustafa Açıkalın, Emel Yaldır, Cavit Can, Nazlı Sena Şeker, ÇOLAK, ERTUĞRUL, Can, Cavit, ÖZEN, ATA   +11 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Predictive Value of Naples Prognostic Score in Determining the Prognosis of Acute Pancreatitis-A Single-Center Experience. [PDF]

J Clin Med
Sargin F, Gok Sargin Z, Caliskan A, Karaduru Avci A, Dogan C, Avci A.   +5 more
europepmc   +1 more source

Development and Internal Validation of a Novel Prognostic Score in Metastatic Colorectal Cancer: A Comparative Retrospective Cohort Study with the Glasgow Prognostic Score and Gustave Roussy Immune Score. [PDF]

J Clin Med
Çokgezer S, Karabulut S.
europepmc   +1 more source