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Prognostic and Predictive Signatures for Treatment Decisions
Biomarkers in Medicine, 2018We develop a subgroup selection procedure using both prognostic and predictive biomarkers to identify four patient subpopulations: low- and high-risk responders, and low- and high-risk nonresponders.We utilize three regression models to identify three sets of biomarkers: S, prognostic biomarkers; T, predictive biomarkers; and U, prognostic and ...
Un Jung, Lee +3 more
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Taking Prognostic Signatures to the Clinic
2020In this chapter, the authors focus on genomic predictors related to prognosis and the way these predictors are expected to impact patient management in the future and accelerate the transition from the “empirical” to “tailored” oncology. Clinicians have long recognized that the diagnosis of breast cancer includes tumor types with different natural ...
Ignatiadis, Michail, Sotiriou, Christos
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Combinatorial Chemistry & High Throughput Screening, 2023
Background: The clinical value of pyroptosis-related genes (PRGs) in lung adenocarcinoma (LUAD) remains obscure. Objective: The study attempts to explore PRGs in LUAD, which will enable an understanding of LUAD from the perspective of PRGs. Method: Lung adenocarcinoma patients were diagnosed using pathology, and their clinical information was ...
Guo-Sheng, Li +12 more
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Background: The clinical value of pyroptosis-related genes (PRGs) in lung adenocarcinoma (LUAD) remains obscure. Objective: The study attempts to explore PRGs in LUAD, which will enable an understanding of LUAD from the perspective of PRGs. Method: Lung adenocarcinoma patients were diagnosed using pathology, and their clinical information was ...
Guo-Sheng, Li +12 more
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Understanding Prognostic Gene Expression Signatures in Lung Cancer
Clinical Lung Cancer, 2009In non-small-cell lung cancer (NSCLC), molecular profiling of tumors has led to the identification of gene expression patterns that are associated with specific phenotypes and prognosis. Such correlations could identify early-stage patients who are at increased risk of disease recurrence and death after complete surgical resection and who might benefit
Chang-Qi, Zhu +7 more
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Nine-Gene Prognostic Signature for Myelodysplastic Syndrome
American Journal of Clinical Pathology, 2023Abstract Introduction/Objective Myelodysplastic Syndrome (MDS) is a family of clonal hematopoietic malignancies found frequently in the seventh and eight decades, supporting that aging and acquired somatic mutations drive development of the disease. Without a cure, the prognosis is poor.
K Lyapichev +7 more
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Prognostic Applications of Gene Expression Signatures in Breast Cancer
Oncology, 2009Analysis by DNA microarrays has led to the identification of molecular subtypes of breast carcinomas that show a distinct expression profile. Several studies have demonstrated that this ‘intrinsic subtype’ classification has a strong prognostic value.
Normanno N. +5 more
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An individualized immune prognostic signature in nasopharyngeal carcinoma
Oral OncologyImmune-related characteristics can serve as reliable prognostic biomarkers in various cancers. Herein, we aimed to construct an individualized immune prognostic signature in nasopharyngeal carcinoma (NPC).This study retrospectively included 455 NPC samples and 39 normal healthy nasopharyngeal tissue specimens. Samples from Gene Expression Omnibus (GEO)
Guanjie Qin +14 more
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MicroRNA prognostic signature in malignant pleural mesothelioma.
Journal of Clinical Oncology, 20157562 Background: Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with asbestos exposure and characterized by a poor outcome (median overall survival (mOS) < 1 year), t...
Francesco Grossi +11 more
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Prognostic Signature for Pancreatic Cancer: Are We Close?
Future Oncology, 2009Pancreatic cancer is a deadly disease with an annual incidence rate nearly equal to its mortality rate. Incremental improvement in outcome has been seen in the last 25 years, illustrating the critical need for novel approaches and intensive research investment.
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Prognostic and Predictive Role of Genetic Signatures
2017A robust body of evidence, initiated by the seminal studies of Dr. Perou’s group at the dawn of the new millennium [1, 2] and repeatedly confirmed over the following decade, has convincingly demonstrated that breast cancer (BC) is a heterogeneous disease further classifiable in at least four molecular intrinsic subtypes (luminal A and B, HER2 enriched,
Giancarlo Pruneri, Francesca Boggio
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