Results 211 to 220 of about 20,102 (279)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Anticipating the Future in an Uncertain Present: How Individuals Living With Medically Unexplained Cognitive Complaints Value Biomarker-Based Prognostics. [PDF]

Health Expect
van der Meer AF, Knippenberg M, Visser D, Boenink M.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A survey of primary care physicians' views on supporting patients who lose insurance coverage for Glucagon-Like Peptide-1-based drugs for weight management. [PDF]

Obes Pillars
Oshman L, Runyon A, Vicenzi Bal A, Arizaca-Dileo P, Sen A, Othman A, Gabison J, Rothberg A, Kraftson A, Griauzde D, Mark Fendrick A.   +10 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Delving into tRNA-derived small RNAs in multiple myeloma: elevated 3'U-tRF^SerTGA leads to poor disease prognosis. [PDF]

Br J Cancer
Soureas K, Malandrakis P, Papadimitriou MA, Ntanasis-Stathopoulos I, Pilala KM, Liacos CI, Gavriatopoulou M, Kastritis E, Dimopoulos MA, Scorilas A, Terpos E, Avgeris M.   +11 more
europepmc   +1 more source

Decision factors for the selection of AI-based decision support systems-The case of task delegation in prognostics. [PDF]

PLoS One
Heinrich K, Janiesch C, Krancher O, Stahmann P, Wanner J, Zschech P.   +5 more
europepmc   +1 more source

A Metric-Driven Evaluation Framework for Remaining Useful Life Prognosis with Quantified Uncertainty. [PDF]

Sensors (Basel)
Vashishtha G, Chauhan S, Ertarğın M.
europepmc   +1 more source

Educational Case: Medulloblastoma. [PDF]

Acad Pathol
Bittner C, Ganapathy S, Baccon J.
europepmc   +1 more source