Results 131 to 140 of about 15,715,755 (294)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Learning to Use Visualizations (an example with elevation and temperature) [PDF]
, 2003 The purpose of this activity is to introduce students to visualizations as a tool for scientific problem-solving, using elevation and temperature as an example.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Seaweed Reproductive Phenology Protocol [PDF]
, 2003 The purpose of this resource is to classify and count the reproductive phenological phases of receptacles on selected seaweed species. Students will classify and count the reproductive phases of seaweed plants within a 1-meter x 1-meter plot in the inter-
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
, 2003 The purpose of this resource is to develop an understanding of some of the relationships between soils of different types and water. Students will time the flow of water through soils with different properties and measure the amount of water held in ...
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Estimating Cloud Cover - a Simulation [PDF]
, 2003 The purpose of this activity is to help students better understand percent cloud cover and to take more accurate cloud cover observations. Working in pairs or small groups, students use construction paper to simulate cloud cover.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source