Results 231 to 240 of about 15,715,755 (294)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

On Gender-Specific FIT Cutoffs in the Swedish Colorectal Cancer Screening Program. [PDF]

United European Gastroenterol J
Brenner H, Ola I, Seum T.
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Nutrition Education for Emerging Adults: Protocol for Program Evaluation.

JMIR Res Protoc
Rogus S, Alfaro Hudak K, Ademu LO, Venkatesh S, Laguros M, Racine EF.   +5 more
europepmc   +1 more source

First Mile program: North-South partnership experience with health system strengthening in Mbarara, Uganda. [PDF]

Glob Health Action
Olds PK, Asiimwe S, Kembabazi A, Ainomugisha A, Ansel J, Ngonzi J, Nambozi G, Mulogo EM, Ntaro M, Santorino D, Atwine R, Obunguloch J, Muhindo R, Kansiime G, Nabulo H, Namagga JK, Sebert M, Kawungezi PC, Turigye B, Wandera DN, Nambogo N, Birungi A, Ivers LC, Obua C.   +23 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

BİLİMSEL PROGRAM / SCIENTIFIC PROGRAM

Turkish Journal of Biochemistry, 2018
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Laying the Foundation for an Elementary School Sleep Education Program. [PDF]

Children (Basel)
Ilie A, Williams P, Rigney G, Weiss SK, Bluden S, Corkum PV.   +5 more
europepmc   +1 more source