Results 161 to 170 of about 37,485,858 (384)

Design standards for low-profile flanges [PDF]

open access: yes, 1974
Analysis of low-profile flange is based on thin shell theory and simple ring theory. Program produces comprehensive design procedure with subsequent stress and deformation analysis.
Prasthofer, W. P.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Метод оценки частоты выполнения фрагментов кода последовательной программы

open access: yesМоделирование и анализ информационных систем, 2010
The goal of this article is to consider the task of determining the execution frequency of program basic blocks. This task is important for such applications as program optimization, paralleling program execution, computing resources allocation, program ...
Alexander Shalimov
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

SURE reliability analysis: Program and mathematics [PDF]

open access: yes
The SURE program is a new reliability analysis tool for ultrareliable computer system architectures. The computational methods on which the program is based provide an efficient means for computing accurate upper and lower bounds for the death state ...
Butler, Ricky W., White, Allan L.
core   +1 more source

A Cost-Effectiveness Analysis of a Pilot Neonatal Screening Program for Sickle Cell Anemia in the Republic of Angola

open access: green, 2015
Patrick T. McGann   +7 more
openalex   +1 more source

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