Results 121 to 130 of about 3,097,676 (317)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Extended Country Program Evaluation Paraguay 2014-2023 [PDF]

open access: yes
This document presents the evaluation conducted by the Office of Evaluation and Oversight (OVE) of the Country Program of the Inter-American Development Bank Group (IDBG) with Paraguay for the 2014-2023 period, spanning two strategic planning periods ...
Inter-American Development Bank
core   +1 more source

Country Program Evaluation: Dominican Republic (2004-2008) [PDF]

open access: yes, 2010
This Country Program Evaluation with the Dominican Republic (RE-371) covers the period from 2004 to 2008 and it\u27s the second evaluation by the Office of Evaluation and Oversight (OVE) of the IDB\u27s programming with the country.
Inter-American Development Bank
core   +1 more source

Global Organizational Psychology: Internationalizing the Training Curriculum

open access: yesPsychological Topics, 2012
Due to the rapid of globalization in the Information Age, students must become adept at navigating the complex and ambiguous nature of the global business environment.
Mavis Kung   +5 more
doaj   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Instruments and Development: An Evaluation of IDB Lending Modalities [PDF]

open access: yes, 2004
The basic objective of this evaluation (RE-300) is to review the range of Bank instruments with respect to the issues of development effectiveness posed by the Governors.
Inter-American Development Bank
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Country Program Evaluation: Paraguay (2003-2008)

open access: yes, 2009
This Country Program Evaluation (RE-356) was produced following OVE\u27s standard protocol for such evaluations. The Evaluation findings are provided as input for Management\u27s charting of the Bank\u27s future strategy with the Republic of Paraguay ...
Inter-American Development Bank
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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