Results 111 to 120 of about 20,667,655 (317)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Shared decision-making and behaviour change collide: an analysis of consultations discussing clinical trial recruitment

Trials
Background Recruitment to clinical trials is often challenging, and evidence on effective recruitment strategies remains limited. Framing trial recruitment as a behaviour, amenable to change, enables the application of behavioural science frameworks to ...
Abigail Stephen, Ayodeji Matuluko, Kelly Carroll, Taylor Coffey, Louisa Lawrie, Frances Sherratt, Natasha Hudek, Fabianna Lorencatto, Justin Presseau, Susan Marlin, Dawn P. Richards, Jamie Brehaut, Katie Gillies   +12 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect and Process Evaluation of e-Powered Parents, a Web-Based Support Program for Parents of Children With a Chronic Kidney Disease: Feasibility Randomized Controlled Trial

, 2018
Wytske W. Geense, Betsie G.I. van Gaal, Jaqueline L Knoll, Nienke Maas-van Schaaijk, Gerjo Kok, Elisabeth A. M. Cornelissen, Maria W. G. Nijhuis–van der Sanden   +6 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Program evaluation of Sea Mar’s Chronic Care Program for Latino and Caucasian patients with type 2 diabetes: providers and staff perspectives

Journal of Multidisciplinary Healthcare, 2012
Gail E Bond,1 Laurie Rechholtz,1 Christina Bosa,1 Celine Impert,1,2 Sara Barker21College of Nursing, Seattle University, Seattle WA, USA; 2Sea Mar Community Health Center, Seattle, WA, USAProblem statement: Unprecedented consumption of health care ...
Bond GE, Rechholtz L, Bosa C, Impert C, Barker S   +4 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Performance of a two-item screening for household food insecurity during WIC services

BMC Public Health
Background The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in California introduced household food insecurity (HFI) screening during eligibility certifications in 2019.
Christopher E. Anderson, M. Pia Chaparro, Shannon E. Whaley   +2 more
doaj   +1 more source

Evaluating Program Progress [PDF]

Public Health Reports (1896-1970), 1955
openaire   +2 more sources

Formative Evaluation of an Inspection Certificate Program (ICP) Pilot in Toronto [PDF]

, 1999
John J. M. Dwyer, Chris Komorowski, Fred Ruf   +2 more
openalex   +1 more source