Results 51 to 60 of about 71,810 (321)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Fault localization approach for null pointer exception

open access: yesTongxin xuebao, 2015
A novel approach to locate the fault for null pointer exception is presented.The approach first computes the static slice guided by the runtime stack,then conducts a null-pointer analysis and aliases analysis on the sliced program and obtains the ...
Shu-juan JIANG   +5 more
doaj   +2 more sources

Graph neural network based approach to automatically assigning common weakness enumeration identifiers for vulnerabilities

open access: yesCybersecurity, 2023
Vulnerability reports are essential for improving software security since they record key information on vulnerabilities. In a report, CWE denotes the weakness of the vulnerability and thus helps quickly understand the cause of the vulnerability ...
Peng Liu   +6 more
doaj   +1 more source

Program specialization via program slicing [PDF]

open access: yes, 1996
This paper concerns the use of program slicing to perform a certain kind of program-specialization operation. We show that the specialization operation that slicing performs is different from the specialization operations performed by algorithms for partial evaluation, supercompilation, bifurcation, and deforestation.
Thomas Reps, Todd Turnidge
openaire   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Diagnostics for stochastic genome-scale modeling via model slicing and debugging. [PDF]

open access: yesPLoS ONE, 2014
Modeling of biological behavior has evolved from simple gene expression plots represented by mathematical equations to genome-scale systems biology networks. However, due to obstacles in complexity and scalability of creating genome-scale models, several
Kevin J Tsai, Chuan-Hsiung Chang
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Test Case Purification for Improving Fault Localization [PDF]

open access: yes, 2014
Finding and fixing bugs are time-consuming activities in software development. Spectrum-based fault localization aims to identify the faulty position in source code based on the execution trace of test cases.
Monperrus, Martin, Xuan, Jifeng
core   +6 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Review on Program Slicing Techniques towards Program Comprehension Application

open access: yesJournal of Computing Research and Innovation, 2018
Presently, the software system has grown in size. One of the main challenges faced by programmers is to keep up with thousand or million lines of source code that needs to be read and understood.
Rozita Kadar   +2 more
doaj  

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