Results 161 to 170 of about 2,677,888 (370)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

open access: yesAdvanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang   +6 more
wiley   +1 more source

PERMANENCIA EN LA UNIVERSIDAD DE HOY [PDF]

open access: yes, 2015
Este artículo presenta los resultados de la investigación denominada “Prácticas pedagógicas en programas de retención estudiantil” cuyo objetivo principal es el de analizar los programas de retención en la Universidad del Rosario (Colombia) y en la ...
ALVARENGA, ANDRÉ MARTINS   +5 more
core  

Assessment portfolio: a novel experience in the Introduction to Comprehensive General Medicine course

open access: yesEdumecentro, 2020
Reference is made to the novel application of the portfolio in the Introduction to Comprehensive General Medicine subject in the first year of the Medicine degree for the evaluation of the in-service training activities.
Milagros Rodríguez Cardenas   +3 more
doaj  

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Estudio del uso de nuevos programas y/o plataformas en la actividad docente [PDF]

open access: yes, 2015
Esta memoria tiene como objetivo describir el trabajo realizado por el equipo que compone la red IGRAC (Investigación sobre Metodología Docente en Imagen Gráfica y Comunicación Publicitaria).
Fortanet van Assendelft de Coningh, Christian   +5 more
core   +1 more source

Unveiling Alkali‐Induced Redox Modulation: In‐Situ Spectroscopic Insights from RWGS on Alkali‐Modified ZrO2‐Supported Cu Catalysts

open access: yesAdvanced Science, EarlyView.
Revisiting the prevailing views that alkali only enhances adsorption properties and stabilizes metal particles against sintering, this study highlights the key role of Na+ in modulating Cu redox properties. Na+ added via wet impregnation (WI) hinders Cu2+ reduction but promotes oxidation and leads to Cu site loss by sintering/coverage. In contrast, the
Abdallah I. M. Rabee   +10 more
wiley   +1 more source

Reducción de programas semiinfinitos a programas finitos [PDF]

open access: yes, 1980
Goberna Torrent, Marco A.   +2 more
core   +2 more sources

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