Results 161 to 170 of about 13,173 (289)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

On offloading control plane applications to the data plane

One of the most active areas in computer networking is Software Defined Networking (SDN). SDN separates the two core functions of a network element (e.g., router): the control-plane and the data-plane.
Gran Alcoz, Albert
core  

Rotational 3D printing of active-passive filaments and lattices with programmable shape morphing. [PDF]

Proc Natl Acad Sci U S A
Abdelrahman MK, Wilt JK, Jung Y, Telles R, Paink GK, Larson NM, Aizenberg J, Mahadevan L, Lewis JA.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

4D injection molding. [PDF]

Nat Commun
Wang J, Zheng K, Liu T, Liu H, Cui H, Li H, Liang Y, Zhou S, Li F, Wang D, Fan C, Shang J, He Q, Cheng Y, Jiang B, Qi J, Chang L, Shuai W.   +17 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

FlxVRM: Enabling online configuring memory via virtualization on programmable data plane

Programmable data plane (PDP) has emerged as a powerful platform for line-rate packet processing, utilizing on-chip register memory to execute stateful applications.
Mimi Qian (13214046), Yuhui Deng (13214049), Lin Cui (163750), Fung Po Tso (3796399), Zhen Zhang (86004), Weijia Jia (7168466)   +5 more
core  

Designing a privacy preserving solution on programmable switches [PDF]

reservedThe use of programmable data planes in network research has led to great innovation in the last decade. With programmable data planes, a network administrator can customise and monitor the lowest-level behaviour of network devices via standard ...
COREGGIOLI, CRISTIAN
core  

Stress-driven photo-reconfiguration of surface microstructures via vectorial field-guided lithography. [PDF]

Light Sci Appl
Januariyasa IK, Reda F, Liubimtsev N, Patel P, Pedersen C, Borbone F, Salvatore M, Saphiannikova M, McGee DJ, Oscurato SL.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source