Results 171 to 180 of about 735,660 (264)

From "synthetic" to defined microbial communities for clearer terminology. [PDF]

Nat Commun
Koch H, Clavel T, Mayr C, Coltman BL, Schloter M, Vorholt JA, Sanz Y, Cernava T, Beattie GA, Lange L, Chaillou S, Kovács ÁT, Smidt H, Pieterse CMJ, Kostic T, Finkel OM, Lawson CE, Cocolin L, Mercado-Blanco J, Finn RD, Papadopoulou KK, Ryan M, Candela M, Cotter PD, Berg G, O'Sullivan O, Delgado-Baquerizo M, Trivedi P, Charles TC, Singh BK, Brader G, Marian M, Sessitsch A.   +32 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A coach-supported, digital parenting programme for parents of adolescents at risk of suicide: pilot trial of acceptability, feasibility, validity and short-term effects. [PDF]

BJPsych Open
Cao A, Melvin GA, Cardamone-Breen M, Salvaris C, Olivier P, Wu L, Seguin J, Xie J, Basur D, Thompson A, Leicester S, Hasking P, Jorm AF, Yap MBH.   +13 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Study protocol for a pragmatic parallel-group randomised controlled trial to evaluate the effectiveness of coaching with an online intervention, compared with the online intervention alone, for families of children who have experienced developmental regression. [PDF]

BMJ Open
Sim WH, Leo M, Bourke-Taylor HM, Bernie C, Brignell A, Ure A, Furley K, Fahey AM, Bhopti A, Odgers S, Picking L, Xie J, Wu L, Yap MBH, Williams K.   +14 more
europepmc   +1 more source

Programme-souvenir, programme d'avenir [PDF]

Relations industrielles, 1947
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Implementing women's sexual and reproductive health interventions in prisons: a realist review. [PDF]

BMJ Open
Rickard J, Melendez-Torres GJ.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Home-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial. [PDF]

J Cachexia Sarcopenia Muscle
Rapp K, Nerz C, Fleiner T, Denkinger M, Büchele G, Rehm M, Mayer B, Rothenbacher D, Grüneberg C, Braun T, Hendlmeier I, Schäufele M, Dams J, König HH, Becker C, Bauer JM, Werner C.   +16 more
europepmc   +1 more source