Results 201 to 210 of about 735,660 (264)

UK National Screening Committee position statement on evidence required for multicancer detection tests.

BMJ
Batson S, Taylor-Phillips S, Mackie A, Given-Wilson R, Halligan S, Hackshaw A, Callender T, Hyde C, Payne K, Visintin C, Thompson D, Evans DG, Richards M, Shinkins B.   +13 more
europepmc   +1 more source

Youth Participation, Agency and Well-Being in Hospital-Linked Contexts: Evidence From the KIDS Programme. [PDF]

Child Care Health Dev
García Expósito L.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Supporting patients using a digital self-management intervention for symptoms of fatigue, pain, and urgency/incontinence in Inflammatory Bowel Disease: a mixed methods process evaluation of trial facilitators. [PDF]

PLoS One
Wileman V, Czuber-Dochan W, Moss-Morris R, Dibley L, McGuinness S, Miller L, Norton C, Taylor SJC.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Developing community-based programme theories to address unmet needs of people experiencing homelessness and severe mental illness: protocol for a realist review. [PDF]

NIHR Open Res
Abayneh S, Asher L, Smartt C, Mutiso V, Yaro PB, Misganaw E, Kariuki K, Mukami F, Fofo CA, Legend TH, Chenu H, Read U, Mayston R, Birhanu R, Alem A, Hanlon C.   +15 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cost-Effectiveness of Nationwide HPV Vaccination in Girls in Kazakhstan: A UNIVAC-Based Analysis. [PDF]

Vaccines (Basel)
Nissanova R, Kassenov M, Suchshikh V, Akshalova P, Abay Z, Kirpichenko V, Karabassova A, Kaimoldina S, Zhetpisbay Z, Bashenova E, Nurpeisova A.   +10 more
europepmc   +1 more source

Prospective use of genomics in the evaluation of sudden cardiac death: results from a national health service population pathway. [PDF]

EBioMedicine
Wade C, Sandford R, Elmslie F, Sheppard MN, Richards CJ, Croal B, Osborn M, Ben-Haim Y, Raymundo CE, Hunt L, Mason C, Cox S, Roe C, Samani NJ, Hill S, Williams B, Behr ER, NHS and Coronial Service Sudden Unexpected Death programme group.   +17 more
europepmc   +1 more source

Reflections on 10 years of research capacity building. [PDF]

NPJ Prim Care Respir Med
Davies GA, Pinnock H, Ferris K, Sheikh A.   +3 more
europepmc   +1 more source