Results 261 to 270 of about 4,862,734 (358)

Black Children's Achievement Programme evaluation [PDF]

, 2009
Maylor, Uvanney
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bridging the gap: a mixed-methods real-world pilot of a digital intervention for adults with binge eating. [PDF]

J Eat Disord
Osborne EL, Powell J, Barker L, Birtwell C, Debrou L, Defever E, Francis V, Hunter E, Kotze N, Lees A, Newell C, Randell B, Rosten C, Yao V, Murphy R.   +14 more
europepmc   +1 more source

Programme scientifique / Wissenschaftliches Programm [PDF]

Dermatologica Helvetica, 2001
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Training Healthcare Professionals to Deliver a Group-Based Intervention for People Living With Severe Obesity: Lessons From the PROGROUP Feasibility Trial. [PDF]

J Hum Nutr Diet
Moghadam S, Tarrant M, Hawkins L, Swancutt D, Sheaff R, Hollands L, Calitri R, Pinkney J, Lloyd J.   +8 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Impact and cost-effectiveness of the community-led AMETHIST intervention among female sex workers in Zimbabwe. [PDF]

Nat Commun
Bansi-Matharu L, Mangenah C, Revill P, Machingura F, Ali S, Chabata ST, Matambanadzo P, Steen R, Mpofu A, Mugurungi O, Taramusi I, Hargreaves JR, Cowan FM, Phillips AN.   +13 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source