Results 21 to 30 of about 1,461,401 (232)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

The Relative Effectiveness of Programmed Instruction Versus the Lecture and Discussion Method on the Assessment Skills and Reporting Patterns of Child Abuse and Neglect Among Undergraduate Nursing Students [PDF]

, 1992
The problem studied in this investigation was whether different instructional methods could increase the assessment skills and affect reporting patterns of child abuse and neglect among undergraduate students majoring in nursing. Two hundred and nineteen
Hammond, Pamela Valleria Wilson
core   +1 more source

The Algorithmic Origins of Life [PDF]

, 2012
Although it has been notoriously difficult to pin down precisely what it is that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property.
Cairns-Smith AG, Campbell DT, Cline DB, Davies PCW, Davies PCW, Ellis GFR, Gesteland RF, Hofstadter D, Kauffman S, Kolmogorov AN, Küppers BO, Paul C. W. Davies, Pearl J, Poundstone W, Sara Imari Walker, Schrödinger E, Segré D, Shaprio R, von Neumann J, Walker SI, Whitesides G   +20 more
core   +1 more source

Instruction sequence size complexity of parity [PDF]

Fundamenta Informaticae, 149(3):297--309, 2016, 2014
Each Boolean function can be computed by a single-pass instruction sequence that contains only instructions to set and get the content of Boolean registers, forward jump instructions, and a termination instruction. Auxiliary Boolean registers are not necessary for this.
arxiv   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Level-of-Aspiration Theory and Initial Stance in Bargaining [PDF]

, 1986
This research focuses on the effect of initial stance in bargaining. Following level-of-aspiration theory, the research examines whether the pattern of early concession making modifies the impact of tough vs. soft initial stance.
Lawler, Edward J, MacMurray, Bruce K
core   +1 more source

Latent Jailbreak: A Benchmark for Evaluating Text Safety and Output Robustness of Large Language Models [PDF]

arXiv, 2023
Considerable research efforts have been devoted to ensuring that large language models (LLMs) align with human values and generate safe text. However, an excessive focus on sensitivity to certain topics can compromise the model's robustness in following instructions, thereby impacting its overall performance in completing tasks. Previous benchmarks for
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Overview of technologies for building robots in the classroom [PDF]

, 2013
This paper aims to give an overview of technologies that can be used to implement robotics within an educational context. We discuss complete robotics systems as well as projects that implement only certain elements of a robotics system, such as ...
Ciocci, Maria-Cristina, Saldien, Jelle, Vanderborght, Bram, Vandevelde, Cesar   +3 more
core   +1 more source