Results 21 to 30 of about 86,395 (208)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development of a game-based learning tool for applied team science communication in a virtual clinical trial. [PDF]

, 2018
Educational tools for application of team science competencies in clinical research are needed. Our interdisciplinary group developed and evaluated acceptability of a virtual world game-based learning tool simulating a multisite clinical trial ...
Depp, Colin A, Dumbauld, Jill, Firestein, David, Firestein, Gary S, Fontanesi, John, Howland, Alex   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Written information about individual medicines for consumers.

, 2009
Medicines are the most common intervention in most health services. As with all treatments, those taking medicines need sufficient information: to enable them to take and use the medicines effectively, to understand the potential harms and benefits, and ...
Al-Eidan, Al-Rashed, Al-Saffar, Angunawela, Anonymous, Arthur, Arthur, Ascione, Atherton-Naji, Azrin, Baker, Barlow, Bellantuono, Bergus, Bernardini, Bernardini, Berry, Berry, Berry, Berry, Berto, Bjorck Linne, Buck, Chin-Quee, Clark, Clementsen, Clinite, Coulter, Crawford, Crichton, Crilly, Culbertson, Demiralay, Demiralay, Desponds, Dickinson, Discenza, Dixon-Woods, Dodds, Dolinsky, Donovan, Eaton, Edworthy, Esposito, Evans, Ferguson, Fincham, Flesch, Forster, Fuchs, Gardner, George, Gibbs, Gibbs, Greenblatt, Gundogar, Haecht, Haecht, Halperin, Hannes, Hartley, Hartzema, Harvey, Hayes, Haynes, Hendler, Hill, Holcomb, Hussain, Hämeen-Anttila, Jacobs, Johnson, Jones, Juni, Kelloway, Kenny, Kirksey, Kirscht, Knapp, Knapp, Koo, Krass, Kumana, Labor, Laher, Lamb, Leal Hernández, Ley, Ley, Lirsac, Little, Little, Littlewood, Lowe, Macfarlane, Macfarlane, Madoff, Mainous, Mansoor, Mansoor, Mansoor, McBean, McCormack, McDonald, Miquel AV Ortín Font, Morris, Morris, Morris, Morrow, Mundt, Murphy, Myers, Myers, Neafsey, Ngoh, NHS, Nicolson, Nicolson, Nightingale, Norell, Oldman, Pander Maat, Parker, Peura, Peveler, Pope, Quaid, Rabol, Raynor, Raynor, Raynor, Raynor, Raynor, Regner, Robinson, Rollins, Ronmark, Royal Pharmaceutical Society of Great Britain and Merck Sharp & Dohme, Ruck, Russell, Sands, Sansgiry, Satterwhite, Saunders, Savage, Savas, Schaffer, Schulz, Segador, Sless, Smith, Smith, Smith, Steering committee for the collaborative development of a long-range action plan, Stratton, Strydom, Strydom, Sukkari, Suppapitiporn, Svarstad, Swanson, Sweileh, Temple, Thomas, Thomas, Thompson, Trollor, Tymchuk, Udkow, Vander Stichele, Vesco, Vivian, Webb, Webber, Whatley, Whiteside, Winkler, Wise, Wissmann, Worsley, Wright, Young, Young, Ziklund-Fisher, Zion, Zondag, Zweifler   +186 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Human variability, task complexity and motivation contribution in manufacturing [PDF]

, 2013
This paper is a preliminary study of the human contribution to variability in manufacturing industry and how motivation and learning play a key role in this contribution.
Case, Keith, Goh, Yee, Mat, Shafizal, Sanchez, Angel   +3 more
core  

Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]

, 2008
A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González, Chittaranjan, Suganthi, Gorski, Sharon M., Hou, Ying-Chen Claire, McCall, Kimberly   +4 more
core   +4 more sources