Results 91 to 100 of about 9,061,188 (344)

Adapting a Polarity Lexicon using Integer Linear Programming for Domain-Specific Sentiment Classification

open access: yesConference on Empirical Methods in Natural Language Processing, 2009
Polarity lexicons have been a valuable resource for sentiment analysis and opinion mining. There are a number of such lexical resources available, but it is often suboptimal to use them as is, because general purpose lexical resources do not reflect ...
Yejin Choi, Claire Cardie
semanticscholar   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Generating Local Search Neighborhood with Synthesized Logic Programs [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2019
Local Search meta-heuristics have been proven a viable approach to solve difficult optimization problems. Their performance depends strongly on the search space landscape, as defined by a cost function and the selected neighborhood operators.
Mateusz Ślażyński   +2 more
doaj   +1 more source

Generic concept to program the time domain of self-assemblies with a self-regulation mechanism.

open access: yesNano letters (Print), 2015
Nature regulates complex structures in space and time via feedback loops, kinetically controlled transformations, and under energy dissipation to allow non-equilibrium processes.
T. Heuser   +4 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Thinking as mental model-building: a Piagetian-cum-mechanistic explanation of the 'engram' [PDF]

open access: yes, 2007
Piaget (like Skinner) appears to deny the relevance or possibility of describing thought in mechanistic terms. Nevertheless, this paper attempts to outline one way in which this might be done for Piaget's concepts.
Traill, RR
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

On solving fully fuzzy multi-criteria De Novo programming via fuzzy goal programming approach

open access: yesJournal of Applied Research on Industrial Engineering, 2018
In this paper, a Multi-Criteria De Novo Linear Programming (F- MDNLP) problem has been developed under consideration of the ambiguity of parameters. These fuzzy parameters are characterized by fuzzy numbers.
Hamiden Abdelwahed Khalifa
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

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