Results 121 to 130 of about 9,061,188 (344)
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Transformational program development in a particular problem domain
Science of Computer Programming, 1986 Transformational programming is a methodology which supports the process of constructing a program that meets a given specification. Starting with a formal problem definition, an algorithm to solve the problem is derived (formally) by applying correctness-preserving transformation rules in a step-by-step fashion.
openaire +2 more sources
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
An exact method for a discrete multiobjective linear fractional optimization [PDF]
Integer linear fractional programming problem with multiple objective MOILFP is an important field of research and has not received as much attention as did multiple objective linear fractional programming.
Chergui, M. E-A, Moulai, M.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Stability in E-convex programming
International Journal of Mathematics and Mathematical Sciences, 2001 We define and analyze two kinds of stability in E-convex programming problem in which the feasible domain is affected by an operator E. The first kind of this stability is that the set of all operators E that make an optimal set stable while the other ...
Ebrahim A. Youness
doaj +1 more source
SIESTA, a time domain, general purpose simulation program for the VIRGO experiment [PDF]
, 1999 Bruce R. Caron +8 more
openalex +1 more source
Learning Strategies and Transfer in the Domain of Programming
Cognition and Instruction, 1994 We report two studies involving an intelligent tutoring system for Lisp (the Camegie Mellon University Lisp Tutor). In Experiment 1, we developed a model, based on production system theories of transfer and analogical problem solving, that accounts for effects of instructional examples, the transfer of cognitive skills across programming problems, and ...
Pirolli, Peter, Recker, Mimi
openaire +3 more sources
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source