Results 81 to 90 of about 682,366 (313)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Generating Local Search Neighborhood with Synthesized Logic Programs [PDF]
Electronic Proceedings in Theoretical Computer Science, 2019 Local Search meta-heuristics have been proven a viable approach to solve difficult optimization problems. Their performance depends strongly on the search space landscape, as defined by a cost function and the selected neighborhood operators.
Mateusz Ślażyński +2 more
doaj +1 more source
Image Segmentation and Classification of Marine Organisms [PDF]
, 2018 To automate the arduous task of identifying and classifying images through their domain expertise, pioneers in the field of machine learning and computer vision invented many algorithms and pre-processing techniques.
Vojjila, Krishna Teja
core +1 more source
Domain-Independent Dynamic Programming
Manuscript submitted to Artificial ...
Kuroiwa, Ryo, Beck, J. Christopher
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Personal knowledge base designer: Software for expert systems prototyping
SoftwareX, 2020 In most cases, the complexity of expert systems engineering depends on the complexity of knowledge base engineering. This process includes formalization and programming tasks.
Aleksandr Yu. Yurin, Nikita O. Dorodnykh
doaj +1 more source
Hop and HipHop : Multitier Web Orchestration [PDF]
, 2013 Rich applications merge classical computing, client-server concurrency, web-based interfaces, and the complex time- and event-based reactive programming found in embedded systems.
Berry, Gérard, Serrano, Manuel
core +3 more sources
Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants in Monosiga brevicollis PDZ Domains Using Human PDZ Data [PDF]
, 2021 Haley A. Wofford +6 more
openalex +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source