Results 41 to 50 of about 7,278 (267)
Harm Reduction Journal, 2020 Background North America and other parts of the globe are in the midst of a public health emergency related to opioid overdoses and a highly contaminated illicit drug supply.
Trevor Goodyear +4 more
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Abstract Dynamic Programming on Partially Ordered Spaces
We study abstract dynamic programs on partially ordered spaces, pairing the order-theoretic approach to dynamic programming with topological and metric foundations. We show that readily verifiable forms of topological stability, such as global stability and contractivity of the policy operators, deliver the fundamental optimality properties of dynamic ...
Peng, Chengyuan +2 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
On singular nonlinear distributional and impulsive initial and boundary value problems
Boundary Value Problems, 2011 Purpose To derive existence and comparison results for extremal solutions of nonlinear singular distributional initial value problems and boundary value problems.
Heikkilä Seppo
doaj
City, Territory and ArchitectureThe purpose of this paper is to examine various approaches to urban design discourses based on everyday practices in limited spaces to contribute to the discussion of sustainable urbanism.
Arnis Rochma Harani +3 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Generic Programming in Space and Time: Abstractions for High Performance Code Generation
, 2017 The development of high performance libraries on modern hardware is extremely difficult and often requires reimplementation or retuning with every new processor generation. Program generators that produce such libraries automatically from a high level description are an appealing solution but only few exist to date. The difficulty is in both the design
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Computational approaches in chemical space exploration for carbon fixation pathways
npj Systems Biology and ApplicationsChemical space exploration is an important part of chemistry and biology, enabling the discovery and optimization of metabolic pathways, advancing synthetic metabolic functions, and understanding biochemical network evolution.
Anne-Susann Abel +5 more
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Control Multimodal en Entornos Inciertos usando Aprendizaje por Refuerzos y Procesos Gaussianos
Revista Iberoamericana de Automática e Informática Industrial RIAI, 2015 Resumen: El control de sistemas complejos puede ser realizado descomponiendo la tarea de control en una secuencia de modos de control, o simplemente modos.
Mariano De Paula +3 more
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