Results 11 to 20 of about 176,997 (194)

kLog: A Language for Logical and Relational Learning with Kernels

, 2014
We introduce kLog, a novel approach to statistical relational learning. Unlike standard approaches, kLog does not represent a probability distribution directly. It is rather a language to perform kernel-based learning on expressive logical and relational
Altun, Ando, Antanas, Antanas, Antanas, Argyriou, Blockeel, Blockeel, Bottou, Boulicaut, Bröcheler, Ceroni, Chang, Chang, Cook, Costa, Costa, De, De Grave, De Grave, De Raedt, De Raedt, De Raedt, Dietterich, Dietterich, Evgeniou, Fabrizio Costa, Frasconi, Frasconi, Friedman, Gross, Gärtner, Gärtner, Haussler, Heckerman, Helma, Helma, Horváth, Joachims, Kazius, Kersting, Kersting, Kersting, Kimmig, Koller, Kordjamshidi, Kou, Kramer, Kurt De Grave, Lanckriet, Landwehr, Lao, Lari, London, Lowd, Luc De Raedt, Luks, Macskassy, Mahe, McCallum, McKay, Menchetti, Mitchell, Muggleton, Muggleton, Neville, Ng, Paolo Frasconi, Quinlan, Ralaivola, Richardson, Rizzolo, Rossi, Serebrenik, Shervashidze, Shi, Sorlin, Srinivasan, Srinivasan, Sun, Sutton, Taskar, Taskar, Tsochantaridis, van de Waterbeemd, Vazquez, Verbeke, Verbeke, Vishwanathan, Wachman, Wang, Wolpert, Yan   +92 more
core   +1 more source

A Comparison of Big Data Frameworks on a Layered Dataflow Model [PDF]

, 2016
In the world of Big Data analytics, there is a series of tools aiming at simplifying programming applications to be executed on clusters. Although each tool claims to provide better programming, data and execution models, for which only informal (and ...
Aldinucci, Marco, Drocco, Maurizio, Misale, Claudia, Tremblay, Guy   +3 more
core   +2 more sources

Constraint Design Rewriting [PDF]

, 2013
We propose an algebraic approach to the design and transformation of constraint networks, inspired by Architectural Design Rewriting. The approach can be understood as (i) an extension of ADR with constraints, and (ii) an application of ADR to the design
Bruni, Roberto, Lluch-Lafuente, Alberto, Montanari, Ugo   +2 more
core  

Symmetric and Synchronous Communication in Peer-to-Peer Networks [PDF]

, 2007
Motivated by distributed implementations of game-theoretical algorithms, we study symmetric process systems and the problem of attaining common knowledge between processes.
Witzel, Andreas
core   +7 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GLC actors, artificial chemical connectomes, topological issues and knots [PDF]

, 2013
Based on graphic lambda calculus, we propose a program for a new model of asynchronous distributed computing, inspired from Hewitt Actor Model, as well as several investigation paths, concerning how one may graft lambda calculus and knot ...
Buliga, Marius, Kauffman, Louis H.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source