Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
California Agriculture, 1951 Part II of a two-part progress report. Part I of this progress report, published in the February 1951 issue of California Agriculture, described the marked improvement observed in the vegetative characteristics of lemon trees receiving soil applications ...
D Aldrich, J Coony
doaj
Mechanoregulated trabecular bone adaptation: Progress report on in silico approaches. [PDF]
Biomater Biosyst, 2022 Smotrova E, Li S, Silberschmidt VV.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Progress report: Grape mechanical harvesting comes closer to reality
California Agriculture, 1962 California Agriculture - All ...
L Lamouria +3 more
doaj
Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial-First progress report. [PDF]
J Clin Hypertens (Greenwich), 2023 Chori BS +27 more
europepmc +1 more source
New York City's Contract for Excellence: Closing the Funding Gap or a Funding Shell Game? [PDF]
, 2009 This report is entitled New York City's Contract for Excellence: Closing the Funding Gap or a Funding Shell Game? The answer to the question posed by the title of the report is "both." The state's Contracts for Excellence funds are promoting educational ...
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Progress Report: Antimicrobial Drug Discovery in the Resistance Era. [PDF]
Pharmaceuticals (Basel), 2022 Shinu P +8 more
europepmc +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source