Results 181 to 190 of about 4,021,724 (320)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Dutch Idiopathic Ventricular Fibrillation Registry: progress report on the quest to identify the unidentifiable. [PDF]
Verheul LM +8 more
europepmc +1 more source
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Progress report on the single transducer ultrasonic thermometer using electrostatic actuator. [PDF]
Voldán M, Husník L, Mahovský D.
europepmc +1 more source
PHYSICS DIVISION SEMIANNUAL PROGRESS REPORT FOR PERIOD ENDING SEPTEMBER 10, 1955
J. L. Fowler, E. O. Wollan
openalex +2 more sources
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source

