Results 91 to 100 of about 1,213,487 (359)

T‐antigen as a biomarker of progression‐free survival in patients with glioblastoma

Annals of Clinical and Translational Neurology
AbstractObjectiveGlioblastoma (GBM) is one of the most aggressive brain tumors and often leads to poor outcomes. Studies have indicated that glycan levels are significantly correlated with the pathogenesis and development of cancers. However, whether glycan levels can serve as diagnostic or prognostic biomarkers in GBM remains unclear.MethodsWe ...
Liao Guan, Wenwen Wang, Xuefei Ji, Hongwei Cheng, Weidong Du, Lei Ye   +5 more
openaire   +3 more sources

Effectiveness and cost-effectiveness of erlotinib versus gefitinib in first-line treatment of epidermal growth factor receptor-activating mutation-positive non-small-cell lung cancer patients in Hong Kong [PDF]

, 2014
OBJECTIVE: To compare the effectiveness and cost-effectiveness of erlotinib versus gefitinib as first-line treatment of epidermal growth factor receptor-activating mutation-positive non-small-cell lung cancer patients. DESIGN.
Lee, VHF, Lee, VWY, Schwander, B
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Diagnostic characteristics, treatment outcomes, and prognostic factors in glucagonomas

Endocrine Oncology
Objective: Glucagonomas are rare islet cell tumours, accounting for 2% of such tumours, with an annual incidence of 0.01–0.1 per million. This study aimed to describe diagnostic characteristics and treatment outcomes in patients with glucagonoma from a ...
Eleni Armeni, Alexander Branton, Juliana Porto, Dalvinder Mandair, Aimee R Hayes, Aspasia Manta, Shaunak Navalkissoor, Gopinath Gnanasegaran, Ann-Marie Quigley, Ashley B Grossman, Martyn Caplin, Christos Toumpanakis   +11 more
doaj   +1 more source

Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021): a multicentric randomized trial [PDF]

, 2016
Despite an improved antitumor efficacy as noticed by an enhanced response rate and an improved progression-free survival, the hepatic intra-arterial fotemustine did not increase the overall survival of uveal melanoma patients with liver metastases only ...
Baurain, J. F., Durando, X., Gurunath, R. Karra, Jouary, T., Kaempgen, E., Keilholz, U., Leyvraz, S., Marshall, E., Negrier, S., Piperno-Neumann, S., Schadendorf, D., Scheulen, M., Suciu, S., Testori, A., Vermorken, J. B., Zdzienicki, M.   +15 more
core   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Prognostic Role of RASSF1A, SOX17 and Wif-1 Promoter Methylation Status in Cell-Free DNA of Advanced Gastric Cancer Patients

Technology in Cancer Research & Treatment, 2021
Epigenetic modification of several genes is a key component in the development of gastric cancer. The methylation status of RASSF1A , SOX17 and Wif-1 genes was evaluated in the cell free circulating DNA of 70 patients with advanced gastric cancer, using ...
Evangelos I. Karamitrousis BSc, MSc, MD, PhD, Ioanna Balgkouranidou BSc, PhD, Nikolaos Xenidis MD, PhD, Kyriakos Amarantidis MD, PhD, Eirini Biziota MD, PhD, Triantafyllia Koukaki MD, Grigorios Trypsianis BSc, PhD, Anastasios Karayiannakis MSc, MD, PhD, Helen Bolanaki MD, George Kolios MD, PhD, Evi Lianidou BSc, MSc, PhD, Stylianos Kakolyris MD, PhD   +11 more
doaj   +1 more source

Cost-effectiveness of [18F] fluoroethyl-L-tyrosine for temozolomide therapy assessment in patients with glioblastoma [PDF]

, 2019
Background and Purpose: Glioblastomas are the most aggressive of all gliomas. The prognosis of these gliomas, which are classified as grade IV tumors by the World Health Organization (WHO), is poor.
Baguet, Tristan, De Vos, Filip, Goethals, Ingeborg, Verhoeven, Jeroen   +3 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Isatuximab, pomalidomide and dexamethasone in the treatment of relapsed/refractory multiple myeloma in real clinical practice [PDF]

Терапевтический архив
Aim. To evaluate the efficacy and tolerability of the combination of isatuximab, pomalidomide, dexamethasone (IsaPd) in the treatment of relapsed refractory multiple myeloma (RRMM) in a real clinical practice. Materials and methods.
Vadim V. Ptushkin, Yulia В. Kochkareva, Ekaterina А. Sukhova, Eugene A. Nikitin   +3 more
doaj   +1 more source