Results 281 to 290 of about 5,027,565 (330)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients. [PDF]

Diabetes Metab Res Rev
Mertens IM, Keymeulen B, Gorus FK, Van De Casteele M, Belgian Diabetes Registry.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Sarcopenia severity and its prognostic value for structural and functional progression in elderly patients with knee osteoarthritis: a 24-month retrospective cohort study. [PDF]

Am J Transl Res
Wen T, Ji J, Tu Y.
europepmc   +1 more source

Resistance to anti-PD-1 immunotherapy for stage III and IV melanoma: a global chart review study. [PDF]

J Immunother Cancer
Gaughan EM, Kim M, Mendez I, Rao AD, Wei M, So A, Zhong X, Berking C, Jiang R, Kim TM, Dalle S, Robert C, Danson S, Alam S, Charles J, Davies T, Debus D, Dzienis M, Frazer R, Gebhardt C, Geidel G, Hassel JC, Hansen I, Heppt MV, Hildebrandt L, Isaacs JM, Suh KJ, Keam B, Kim YJ, Lesimple T, Saiag P, Delibes A, Barnett R, Krepler C, Gandhi K, Qizilbash N, Shui IM, Tan XL, Sullivan RJ.   +38 more
europepmc   +1 more source

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review). [PDF]

Oncol Rep
Xia Z, Zhai H, Zheng L, Wang C.
europepmc   +1 more source

Dietary patterns and longitudinal frailty progression in older Chinese adults: a nationwide cohort study. [PDF]

J Nutr Health Aging
Sheng Y, Wang Y, Di K, Li C, Liu D.
europepmc   +1 more source

Thrombomodulin Mitigates the Progression of Hepatocellular Carcinoma in Steatotic Liver. [PDF]

J Hepatocell Carcinoma
Yamaguchi M, Tashiro H, Kuroda S, Kobayashi T, Hinoi T, Honda G, Ohdan H.   +6 more
europepmc   +1 more source

Interstitial lung abnormalities: to treat or not to treat? The hamlet dilemma. [PDF]

Front Med (Lausanne)
Zanini U, Franco G, Pirotta C, Passeri E, Mazzotta SM, Ferrara G, Mura M, Faverio P, Luppi F.   +8 more
europepmc   +1 more source