Results 231 to 240 of about 1,254,012 (356)

Advanced ovarian cancer with malignant bowel obstruction treated with multidisciplinary therapy resulting in long progression-free survival: a case report. [PDF]

BMC Womens Health
Liu J, Ren W, Zan N, Tian J, Zhang X.
europepmc   +1 more source

D3.1.1 Progression Free Survival (PFS) read out

D311 Progression Free Survival PFS read ...
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Patient-reported outcomes as prognostic indicators for overall survival and progression-free survival in brain tumor patients - a systematic review and meta-analysis of randomized clinical trials. [PDF]

J Neurooncol
Sanikommu S, Santos AN, Wipplinger C, Dawoud B, Komotar RJ, Lu VM.   +5 more
europepmc   +1 more source

Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer [PDF]

Ryota Shibaki, Daichi Fujimoto, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Junya Fukuoka, Yuki Sato, Takashi Kijima, Hirotaka Matsumoto, Toshihide Yokoyama, Satoru Miura, Akito Hata, Motohiro Tamiya, Yoshihiko Taniguchi, Jun Sugisaka, Naoki Furuya, Hisashi Tanaka, Nobuyuki Yamamoto, Yasuhiro Koh, Hiroaki Akamatsu   +19 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pre-treatment cytokines plus TPSA predict biochemical progression-free survival in prostate cancer metastasis and discriminate metastatic status: a retrospective study. [PDF]

Front Immunol
Mao KF, Sun J, Sun C, Sun BB, Wu ZG, Cai J, Zhou CF.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Evaluation of progression-free survival as a surrogate endpoint for overall survival in small cell lung cancer: a systematic review. [PDF]

J Thorac Dis
Lin G, Ge F, Yang C, Huang Y.
europepmc   +1 more source

MRI Radiomics and Nutritional-Inflammatory Biomarkers: A Powerful Combination for Predicting Progression-Free Survival in Cervical Cancer Patients Undergoing Concurrent Chemoradiotherapy [PDF]

Qi Yan, Menghan Wu, Jing Zhang, Jiayang Yang, Guannan Lv, Baojun Qu, Yanping Zhang, Yan Xia, Jianbo Song   +8 more
openalex   +1 more source