Results 261 to 270 of about 1,254,012 (356)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A randomized Bayesian phase I-II dose optimization design for combination cancer therapies with progression-free survival end point. [PDF]

BMC Med Res Methodol
Qiu Y, Li M.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

How to predict progression-free survival in patients with grade 2 IDH-mutated diffuse gliomas after surgery: a long-term follow-up analysis. [PDF]

Front Oncol
Aprile M, Di Nunno V, Gatto L, Tosoni A, Balestrini D, Ramponi V, Conti A, Maffei M, Battaglia S, Argento CM, Zuliani E, Bartolini S, Margotti M, Gentilini F, Tallini G, Asioli S, Franceschi E.   +16 more
europepmc   +1 more source

Kaplan-Meier curve of progression-free survival according to <i>TERT</i> rs2736109 polymorphism in (a) overall 1004 patients and (b) age > 58 supgroup.

, 2015
Xueying Zhao, Shiming Wang, Junjie Wu, M Kellis, Xun Wang, Zhiqiang Gao, Wenting Wu, Haijian Wang, Jiucun Wang, Ji Qian, Ke Ma, Hui Li, Baohui Han, Bai Chunxue, Qiang Li, Wenbin Liu, Lu Daru   +16 more
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Development and validation of an interpretable machine learning model for predicting progression-free survival after immunotherapy in patients with non-small cell lung cancer: a multicenter study. [PDF]

Front Immunol
Li Y, Xia J, He T, Hu Y, Zhou D, Zou D, Li B, Zhang M, Huang Z, Zhang M, Liu X, Wang M, Luo H, Lu F, Zhang C, Zhao X, Su S, Peng J.   +17 more
europepmc   +1 more source

Predicting Progression-free Survival in Primary Liver Cancer Patients via Radiomics from DSA during TACE [PDF]

Yongfa Liu, Cheng Cui, Benjian Gao, Bin Luo, Fangyi Peng, Shuai Hu, Linxin Liu, Xue-cheng Bai, Yaling Li, Xiaoli Yang, Bo Li   +10 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Comparisons of treatment performance and therapy sequences in neuroendocrine neoplasms using progression-free survival ratios. [PDF]

Eur J Nucl Med Mol Imaging
Melhorn P, Kretschmer-Chott E, Mazal P, Raderer M, Kiesewetter B.   +4 more
europepmc   +1 more source